Leptin and the development of obesity and diabetes in Psammomys obesus

Collier, Greg R., Walder, Ken, Lewandowski, Paul, Sanigorski, Andrew and Zimmet, Paul 1997, Leptin and the development of obesity and diabetes in Psammomys obesus, Obesity research, vol. 5, no. 5, pp. 455-458.

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Title Leptin and the development of obesity and diabetes in Psammomys obesus
Author(s) Collier, Greg R.
Walder, Ken
Lewandowski, Paul
Sanigorski, Andrew
Zimmet, Paul
Journal name Obesity research
Volume number 5
Issue number 5
Start page 455
End page 458
Total pages 4
Publisher North American Association for the Study of Obesity
Place of publication Silver Spring, Md.
Publication date 1997-09
ISSN 1071-7323
1930-739X
Keyword(s) leptin
diabetes
Psammomys obesus
Summary The recently discovered ob gene and its circulating product, leptin, may be critical factors in the control of energy balance. Recent studies in ob/ob mice, which lack circulating leptin, have shown dramatic reductions in food intake and bodyweight after leptin treatment. In addition, studies in both humans with obesity and animal models of obesity have demonstrated hyperleptinemia. Here, we report a longitudinal study examining changes in circulating leptin during the development of obesity and diabetes in Psammomys obesus. Over the 8 weeks of the study, lean animals increased their bodyweight by 154% and leptin levels remained essentially unchanged. In contrast, animals that developed obesity (223 % increase in bodyweight), hyperglycemia, and hyperinsulinemia also developed hyperleptinemia between 4 weeks and 8 weeks of age. These results demonstrate that the development of hyperleptinemia is associated with the development of obesity and subsequent metabolic abnormalities.
Language eng
Field of Research 111103 Nutritional Physiology
Socio Economic Objective 920411 Nutrition
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30053023

Document type: Journal Article
Collection: School of Nutrition and Public Health
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