Leptin and the development of obesity and diabetes in Psammomys obesus Collier, Greg R., Walder, Ken, Lewandowski, Paul, Sanigorski, Andrew and Zimmet, Paul 1997, Leptin and the development of obesity and diabetes in Psammomys obesus, Obesity research, vol. 5, no. 5, pp. 455-458, doi: 10.1002/j.1550-8528.1997.tb00670.x. Attached Files Name Description MIMEType Size Downloads Title Leptin and the development of obesity and diabetes in Psammomys obesus Author(s) Collier, Greg R. Walder, Ken Lewandowski, Paul Sanigorski, Andrew Zimmet, Paul Journal name Obesity research Volume number 5 Issue number 5 Start page 455 End page 458 Total pages 4 Publisher North American Association for the Study of Obesity Place of publication Silver Spring, Md. Publication date 1997-09 ISSN 1071-7323 1930-739X Keyword(s) leptin diabetes Psammomys obesus Summary The recently discovered ob gene and its circulating product, leptin, may be critical factors in the control of energy balance. Recent studies in ob/ob mice, which lack circulating leptin, have shown dramatic reductions in food intake and bodyweight after leptin treatment. In addition, studies in both humans with obesity and animal models of obesity have demonstrated hyperleptinemia. Here, we report a longitudinal study examining changes in circulating leptin during the development of obesity and diabetes in Psammomys obesus. Over the 8 weeks of the study, lean animals increased their bodyweight by 154% and leptin levels remained essentially unchanged. In contrast, animals that developed obesity (223 % increase in bodyweight), hyperglycemia, and hyperinsulinemia also developed hyperleptinemia between 4 weeks and 8 weeks of age. These results demonstrate that the development of hyperleptinemia is associated with the development of obesity and subsequent metabolic abnormalities. Language eng DOI 10.1002/j.1550-8528.1997.tb00670.x Field of Research 111103 Nutritional Physiology Socio Economic Objective 920411 Nutrition HERDC Research category C1.1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30053023 Document type: Journal Article Collection: School of Nutrition and Public Health Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 19 Jun 2013, 10:27:44 EST Wed, 19 Jun 2013, 15:26:43 EST Thu, 20 Jun 2013, 11:01:32 EST Thu, 20 Jun 2013, 11:38:38 EST Fri, 13 Jun 2014, 17:32:12 EST Wed, 21 Oct 2015, 14:48:27 EST Filtered Full Citation counts:   Cited 16 times in TR Web of Science Cited 16 times in Scopus Search Google Scholar Access Statistics: 56 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Wed, 19 Jun 2013, 10:27:33 EST by Paul Lewandowski

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