Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity

Eppel, Gabriela A., Armitage, James A., Eikelis, Nina, Head, Geoffrey A. and Evans, Roger G. 2013, Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity, Hypertension research, vol. 36, pp. 588-595.

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Title Progression of cardiovascular and endocrine dysfunction in a rabbit model of obesity
Author(s) Eppel, Gabriela A.
Armitage, James A.
Eikelis, Nina
Head, Geoffrey A.
Evans, Roger G.
Journal name Hypertension research
Volume number 36
Start page 588
End page 595
Total pages 8
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2013
ISSN 0916-9636
1348-4214
Keyword(s) atrial natriuretic peptide
dual - energy X-ray absorptometry
insulin
leptin
renin-angiotensin-aldosterone system
Summary In rabbits, mean arterial pressure (MAP) increases in response to fat feeding, but does not increase further with progressive weight gain. We documented the progression of adiposity and the alterations in endocrine/cardiovascular function in response to fat feeding in rabbits, to determine whether stabilization of MAP after 3 weeks could be explained by stabilization of neurohormonal factors. Rabbits were fed a control diet or high-fat diet for 9 weeks (n¼23). Fat feeding progressively increased body mass and adiposity. Heart rate (HR) was elevated by week 3 (15±3%) but changed little thereafter. The effects of fat feeding on MAP were dependent on baseline MAP and peaked at 3 weeks. From baseline, MAP p80mmHg, MAP had increased by 8.1±1.3, 4.7±1.7 and 5.6±1.2mmHg, respectively, 3, 6 and 9 weeks after commencing the high-fat diet, but by only 2.6±1.5, 3.0±1.7 and 3.9±1.4mmHg, respectively, in control rabbits. Fat feeding did not increase MAP from a baseline 480mmHg. Plasma concentrations of leptin and insulin increased during the first 3–6 weeks of fat feeding and then stabilized (increasing by 111±17% and 731±302% by week 9, respectively), coinciding with the pattern of changes in MAP and HR. Plasma total cholesterol, triglycerides, renin activity, aldosterone and atrial natriuretic peptide were not significantly altered by fat feeding. Given that the changes in plasma leptin and insulin mirrored the changes in MAP and HR, leptin and insulin may be important factors in the development of hypertensionand tachycardia in the rabbit model of obesity.
Language eng
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30053677

Document type: Journal Article
Collection: School of Medicine
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