Reduced preprandial dipping accounts for rapid elevation of blood pressure and renal sympathetic nerve activity in rabbits fed a high-fat diet

Burke, Sandra L., Prior, Larissa J., Lukoshkova, Elena V., Lim, Kyungjoon, Barzel, Benjamin, Davern, Pamela J., Armitage, James A. and Head, Geoffrey A. 2013, Reduced preprandial dipping accounts for rapid elevation of blood pressure and renal sympathetic nerve activity in rabbits fed a high-fat diet, Chronobiology international, vol. 30, no. 5, pp. 726-738.

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Title Reduced preprandial dipping accounts for rapid elevation of blood pressure and renal sympathetic nerve activity in rabbits fed a high-fat diet
Author(s) Burke, Sandra L.
Prior, Larissa J.
Lukoshkova, Elena V.
Lim, Kyungjoon
Barzel, Benjamin
Davern, Pamela J.
Armitage, James A.
Head, Geoffrey A.
Journal name Chronobiology international
Volume number 30
Issue number 5
Start page 726
End page 738
Total pages 13
Publisher Informa Healthcare
Place of publication London, England
Publication date 2013-06
ISSN 0742-0528
1525-6073
Keyword(s) 24-hour rhythm
blood pressure
heart rate
obesity
rabbits
sympathetic nervous system
Summary Consumption of a high-fat diet (HFD) by rabbits results in increased blood pressure (BP), heart rate (HR), and renal sympathetic nerve activity (RSNA) within 1 wk. Here, we determined how early this activation occurred and whether it was related to changes in cardiovascular and neural 24-h rhythms. Rabbits were meal-fed a HFD for 3 wks, then a normal-fat diet (NFD) for 1 wk. BP, HR, and RSNA were measured daily in the home cage via implanted telemeters. Baseline BP, HR, and RSNA over 24 h were 71 ± 1 mm Hg, 205 ± 4 beats/min and 7 ± 1 normalized units (nu). The 24-h pattern was entrained to the feeding cycle and values increased from preprandial minimum to postprandial maximum by 4 ± 1 mm Hg, 51 ± 6 beats/min, and 1.6 ± .6 nu each day. Feeding of a HFD markedly diminished the preprandial dip after 2 d (79–125% of control; p < 0.05) and this reduction lasted for 3 wks of HFD. Twenty-four-hour BP, HR, and RSNA concurrently increased by 2%, 18%, and 22%, respectively. Loss of preprandial dipping accounted for all of the BP increase and 50% of the RSNA increase over 3 wks and the 24-h rhythm became entrained to the light-dark cycle. Resumption of a NFD did not alter the BP preprandial dip. Thus, elevated BP induced by a HFD and mediated by increased sympathetic nerve activity results from a reduction in preprandial dipping, from the first day. Increased calories, glucose, insulin, and leptin may account for early changes, whereas long-term loss of dipping may be related to increased sensitivity of sympathetic pathways.


Language eng
Field of Research 110201 Cardiology (incl Cardiovascular Diseases)
Socio Economic Objective 920103 Cardiovascular System and Diseases
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30053694

Document type: Journal Article
Collection: School of Medicine
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Created: Mon, 15 Jul 2013, 15:31:43 EST by Barb Lavelle

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