Current status of biotechnological production of the cholesterol lowering drug lovastatin and its biomedical applications

Verma, Madan Lal, Jana, Asim Kumar and Kanwar, Shamsher Singh 2010, Current status of biotechnological production of the cholesterol lowering drug lovastatin and its biomedical applications, in BEATS 2010 : Proceedings of the 2010 International Conference on Biomedical Engineering and Assistive Technologies, Jalandhar, India, BEATS, Jalandhar, India, pp. 1-6.

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Title Current status of biotechnological production of the cholesterol lowering drug lovastatin and its biomedical applications
Author(s) Verma, Madan Lal
Jana, Asim Kumar
Kanwar, Shamsher Singh
Conference name Biomedical Engineering and Assistive Technologies. Conference (2010 : Jalandhar, India)
Conference location Jalandhar, India
Conference dates 17-19 Dec. 2010
Title of proceedings BEATS 2010 : Proceedings of the 2010 International Conference on Biomedical Engineering and Assistive Technologies, Jalandhar, India
Editor(s) [Unknown]
Publication date 2010
Conference series Biomedical Engineering and Assistive Technologies Conference
Start page 1
End page 6
Total pages 6
Publisher BEATS
Place of publication Jalandhar, India
Keyword(s) words-Cholesterol lowering drug
biotechnological production
biomedical applications
Summary Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. It acts by competitively inhibiting the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in the biosynthesis of cholesterol. It is produced by a variety of filamentous fungi including Penicillium species, Monascus ruber and Aspergillus terreus as a secondary metabolite. Production of lovastatin by biotechnology decreases the production cost compared to costs of chemical synthesis. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone turnover, neovascularization, vascular tone, and arterial pressure. This review focus on the structure, biosynthesis, biotechnological production and biomedical applications of lovastatin.
Language eng
Field of Research 100301 Biocatalysis and Enzyme Technology
100306 Industrial Molecular Engineering of Nucleic Acids and Proteins
100703 Nanobiotechnology
Socio Economic Objective 860106 Oils and Fats (incl. Margarines)
HERDC Research category E1.1 Full written paper - refereed
Persistent URL http://hdl.handle.net/10536/DRO/DU:30054432

Document type: Conference Paper
Collection: School of Life and Environmental Sciences
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