Elastin and collagen enhances electrospun aligned polyurethane as scaffolds for vascular graft

Wong, Cynthia, Liu, Xin, Xu, Zhiguang, Lin, Tong and Wang, Xungai 2013, Elastin and collagen enhances electrospun aligned polyurethane as scaffolds for vascular graft, Journal of materials science: materials in medicine, vol. 24, no. 8, pp. 1865-1874.

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Title Elastin and collagen enhances electrospun aligned polyurethane as scaffolds for vascular graft
Author(s) Wong, Cynthia
Liu, Xin
Xu, Zhiguang
Lin, Tong
Wang, Xungai
Journal name Journal of materials science: materials in medicine
Volume number 24
Issue number 8
Start page 1865
End page 1874
Total pages 10
Publisher Springer US
Place of publication New York, N. Y.
Publication date 2013-08
ISSN 0957-4530
1573-4838
Keyword(s) synthetic vascular graft
arteries
aligned nanofibrous polyurethane scaffolds
elastin
collagen
Summary Mismatch in mechanical properties between synthetic vascular graft and arteries contribute to graft failure. The viscoelastic properties of arteries are conferred by elastin and collagen. In this study, the mechanical properties and cellular interactions of aligned nanofibrous polyurethane (PU) scaffolds blended with elastin, collagen or a mixture of both proteins were examined. Elastin softened PU to a peak stress and strain of 7.86 MPa and 112.28 % respectively, which are similar to those observed in blood vessels. Collagen-blended PU increased in peak stress to 28.14 MPa. The growth of smooth muscle cells (SMCs) on both collagen-blended and elastin/collagen-blended scaffold increased by 283 and 224 % respectively when compared to PU. Smooth muscle myosin staining indicated that the cells are contractile SMCs which are favored in vascular tissue engineering. Elastin and collagen are beneficial for creating compliant synthetic vascular grafts as elastin provided the necessary viscoelastic properties while collagen enhanced the cellular interactions.
Language eng
Field of Research 091205 Functional Materials
091209 Polymers and Plastics
090301 Biomaterials
Socio Economic Objective 860406 Synthetic Fibres, Yarns and Fabrics
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30054472

Document type: Journal Article
Collection: Institute for Frontier Materials
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Created: Thu, 18 Jul 2013, 14:10:47 EST by Christine Rimmer

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