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Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis

Soh, Sze-Ee, McGinley, Jennifer L., Watts, Jennifer J., Iansek, Robert, Murphy, Anna T., Menz, Hylton B., Huxham, Frances and Morris, Meg E. 2013, Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis, Quality of life research, vol. 22, no. 7, pp. 1543-1553, doi: 10.1007/s11136-012-0289-1.

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Title Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis
Author(s) Soh, Sze-Ee
McGinley, Jennifer L.
Watts, Jennifer J.ORCID iD for Watts, Jennifer J. orcid.org/0000-0001-8095-8638
Iansek, Robert
Murphy, Anna T.
Menz, Hylton B.
Huxham, Frances
Morris, Meg E.
Journal name Quality of life research
Volume number 22
Issue number 7
Start page 1543
End page 1553
Total pages 11
Publisher Springer Science & Business Media
Place of publication Dordrecht, The Netherlands
Publication date 2013-09
ISSN 0962-9343
1573-2649
Keyword(s) Parkinson's disease
quality of life
path analysis
PDQ-39
Summary Purpose:
To identify the demographic factors, impairments and activity limitations that contribute to health-related quality of life (HRQOL) in people with idiopathic Parkinson’s disease (PD).

Method:
Two hundred and ten individuals with idiopathic PD who participated in the baseline assessment of a randomized clinical trial were included. The Parkinson’s Disease Questionnaire-39 summary index was used to quantify HRQOL. In order to provide greater clarity regarding the determinants of HRQOL, path analysis was used to explore the relationships between the various predictors in relation to the functioning and disability framework of the International Classification of Functioning model.

Results:
The two models of HRQOL that were examined in this study had a reasonable fit with the data. Activity limitations were found to be the strongest predictor of HRQOL. Limitations in performing self-care activities contributed the most to HRQOL in Model 1 (β = 0.38; p < 0.05), while limitations in functional mobility had the largest contribution in Model 2 (β = −0.31; p < 0.0005). Self-reported history of falls was also found to have a significant and direct relationship with HRQOL in both models (Model 1 β = −0.11; p < 0.05; Model 2 β = −0.21; p < 0.05).

Conclusions:
Health-related quality of life in PD is associated with self-care limitations, mobility limitations, self-reported history of falls and disease duration. Understanding how these factors are inter-related may assist clinicians focus their assessments and develop strategies that aim to minimize the negative functional and social sequelae of this debilitating disease.
Language eng
DOI 10.1007/s11136-012-0289-1
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30054597

Document type: Journal Article
Collection: School of Health and Social Development
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