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Study protocol for "Moving bright, eating smart"- a phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer survivors

Ho, Judy W.C., Lee, Antoinette M., Macfarlane, Duncan J., Fong, Daniel Y.T., Leung, Sharron, Cerin, Ester, Chan, Wynnie Y.Y., Leung, Ivy P.F., Lam, Sharon H.S., Taylor, Aliki J. and Cheung, Kar-keung 2013, Study protocol for "Moving bright, eating smart"- a phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer survivors, BMC public health, vol. 13, no. 1, Article 487, pp. 1-10.

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Title Study protocol for "Moving bright, eating smart"- a phase 2 clinical trial on the acceptability and feasibility of a diet and physical activity intervention to prevent recurrence in colorectal cancer survivors
Author(s) Ho, Judy W.C.
Lee, Antoinette M.
Macfarlane, Duncan J.
Fong, Daniel Y.T.
Leung, Sharron
Cerin, Ester
Chan, Wynnie Y.Y.
Leung, Ivy P.F.
Lam, Sharon H.S.
Taylor, Aliki J.
Cheung, Kar-keung
Journal name BMC public health
Volume number 13
Issue number 1
Season Article 487
Start page 1
End page 10
Total pages 10
Publisher BioMed Central
Place of publication London, England
Publication date 2013
ISSN 1471-2458
Keyword(s) colorectal cancer
cancer survivor
diet
meat
grains
physical activity
behavioural intervention
feasibility
acceptability
randomised
Summary Background: Colorectal cancer is the second most common cancer and cancer-killer in Hong Kong with an alarming increasing incidence in recent years. The latest World Cancer Research Fund report concluded that foods low in fibre, and high in red and processed meat cause colorectal cancer whereas physical activity protects against
colon cancer. Yet, the influence of these lifestyle factors on cancer outcome is largely unknown even though cancer survivors are eager for lifestyle modifications. Observational studies suggested that low intake of a Western-pattern diet and high physical activity level reduced colorectal cancer mortality. The Theory of Planned
Behaviour and the Health Action Process Approach have guided the design of intervention models targeting a wide range of health-related behaviours.
Methods/design: We aim to demonstrate the feasibility of two behavioural interventions intended to improve colorectal cancer outcome and which are designed to increase physical activity level and reduce consumption of a Western-pattern diet. This three year study will be a multicentre, randomised controlled trial in a 2x2 factorial
design comparing the “Moving Bright, Eating Smart” (physical activity and diet) programme against usual care. Subjects will be recruited over a 12-month period, undertake intervention for 12 months and followed up for a further 12 months. Baseline, interim and three post-intervention assessments will be conducted. Two hundred and twenty-two colorectal cancer patients who completed curative treatment without evidence of recurrence will be recruited into the study. Primary outcome measure will be whether physical activity and dietary targets are met at the end of the 12-month intervention. Secondary outcome measures include the magnitude and
mechanism of behavioural change, the degree and determinants of compliance, and the additional health benefits and side effects of the intervention.
Discussion: The results of this study will establish the feasibility of targeting the two behaviours (diet and physical activity) and demonstrate the magnitude of behaviour change. The information will facilitate the design of a further larger phase III randomised controlled trial with colorectal cancer outcome as the study endpoint to determine whether this intervention model would reduce colorectal cancer recurrence and mortality.
Language eng
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 920401 Behaviour and Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30054897

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.