Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women

Gunardi, A. J., Brennan, S. L., Wang, Y., Cicuttini, F. M., Pasco, J. A., Kotowicz, M. A., Nicholson, G. C. and Wluka, A. E. 2013, Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women, International journal of obesity, vol. 37, pp. 1586-1589.

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Title Associations between measures of adiposity over 10 years and patella cartilage in population-based asymptomatic women
Author(s) Gunardi, A. J.
Brennan, S. L.
Wang, Y.
Cicuttini, F. M.
Pasco, J. A.
Kotowicz, M. A.
Nicholson, G. C.
Wluka, A. E.
Journal name International journal of obesity
Volume number 37
Start page 1586
End page 1589
Total pages 4
Publisher Nature Publishing Group
Place of publication London, England
Publication date 2013
ISSN 0307-0565
1476-5497
Keyword(s) body mass index
adiposity
patella
magnetic resonance imaging
Summary Objective: Osteoarthritis (OA) most commonly affects the patellofemoral compartment of the knee, and is a major cause of pain and disability. Structural changes that evolve prior to the onset of symptoms can be visualised using magnetic resonance imaging (MRI). There is little known information about the role of adiposity on the early structural changes in the patella cartilage in younger, asymptomatic adult females.

Methods: One hundred and sixty asymptomatic women (20–49 years) participating in the Geelong Osteoporosis Study underwent knee MRI (2006–8). Weight and body mass index (BMI) were measured 10 years prior (1994–7, baseline) and at the time of MRI (current), with change over the period calculated (current–baseline). Relationships between measures of adiposity and patella cartilage volume and defects were examined.

Results: After adjustment for age and patella bone volume, there was a reduction of 13 ml (95% confidence interval (95% CI), −25.7, −0.55) in patella cartilage volume for every 1 unit increase in current BMI, and a reduction of 27 ml (95% CI −52.6, −1.5) per BMI unit increase over 10 years (P=0.04 for both). No significant association was observed between baseline BMI and patella cartilage volume (P=0.16). Increased baseline and current weight and BMI were associated with increased prevalence of patella cartilage defects (all P<0.001).

Conclusions: Adiposity and weight gain during midlife are associated with detrimental structural change at the patella in young to middle-aged healthy non-osteoarthritic women. Maintaining a healthy weight and avoiding weight gain in younger asymptomatic women may be important in the prevention of patellofemoral OA.
Language eng
Field of Research 111706 Epidemiology
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30054921

Document type: Journal Article
Collection: School of Medicine
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