Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction Papazzo, Annateresa, Conlan, Xavier A., Lexis, Louise, Charchar, Fadi J. and Lewandowski, Paul A. 2013, Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction, PLoS one, vol. 8, no. 6, pp. 1-9, doi: 10.1371/journal.pone.0066655. Attached Files Name Description MIMEType Size Downloads papazzo-saltloadingincanolaoil-2013.pdf Published version application/pdf 2.70MB 98 Title Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction Author(s) Papazzo, Annateresa Conlan, Xavier A. orcid.org/0000-0003-0829-0551 Lexis, Louise Charchar, Fadi J. Lewandowski, Paul A. Journal name PLoS one Volume number 8 Issue number 6 Start page 1 End page 9 Total pages 9 Publisher Public Library of Science Place of publication San Francisco, Calif. Publication date 2013 ISSN 1932-6203 Summary This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22phox, NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22phox mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 - generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model. Language eng DOI 10.1371/journal.pone.0066655 Field of Research 059999 Environmental Sciences not elsewhere classified Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2013, Public Library of Science (PLoS) Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30055322 Document type: Journal Article Collections: Faculty of Health Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Open Access Collection Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 27 Aug 2013, 11:59:22 EST Tue, 27 Aug 2013, 15:54:57 EST Fri, 17 Oct 2014, 12:19:07 EST Wed, 21 Oct 2015, 18:14:35 EST Wed, 18 Nov 2015, 07:32:17 EST Fri, 18 Mar 2016, 08:28:03 EST Fri, 26 Aug 2016, 15:09:32 EST Mon, 05 Sep 2016, 15:56:23 EST Tue, 06 Sep 2016, 21:25:30 EST Fri, 07 Sep 2018, 12:06:26 EST Filtered Full Citation counts:   Cited 3 times in TR Web of Science Cited 3 times in Scopus Search Google Scholar Access Statistics: 532 Abstract Views, 98 File Downloads  -  Detailed Statistics Created: Tue, 27 Aug 2013, 11:59:22 EST

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