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Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction Papazzo, Annateresa, Conlan, Xavier A., Lexis, Louise, Charchar, Fadi J. and Lewandowski, Paul A. 2013, Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction, PLoS one, vol. 8, no. 6, pp. 1-9. Title Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction Author(s) Papazzo, Annateresa Conlan, Xavier A. Lexis, Louise Charchar, Fadi J. Lewandowski, Paul A. Journal name PLoS one Volume number 8 Issue number 6 Start page 1 End page 9 Total pages 9 Publisher Public Library of Science Place of publication San Francisco, Calif. Publication date 2013 ISSN 1932-6203 Summary This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22phox, NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22phox mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 - generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model. Language eng Field of Research 059999 Environmental Sciences not elsewhere classified Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30055322 Document type: Journal Article Collections: Faculty of Health School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 27 Aug 2013, 11:59:22 EST Tue, 27 Aug 2013, 15:54:57 EST Filtered Full Access Statistics: 5 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Tue, 27 Aug 2013, 11:59:22 EST

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