In vitro strain measurements in cerebral aneurysm models for cyber-physical diagnosis

Shi, Chaoyang, Kojima, Masahiro, Anzai, Hitomi, Tercero, Carlos, Ikeda, Seiichi, Ohta, Makoto, Fukuda, Toshio, Arai, Fumihito, Najdovski, Zoran, Negoro, Makoto and Irie, Keiko 2013, In vitro strain measurements in cerebral aneurysm models for cyber-physical diagnosis, International journal of medical robotics and computer assisted surgery, vol. 9, no. 2, pp. 213-222, doi: 10.1002/rcs.1487.

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Title In vitro strain measurements in cerebral aneurysm models for cyber-physical diagnosis
Author(s) Shi, Chaoyang
Kojima, Masahiro
Anzai, Hitomi
Tercero, Carlos
Ikeda, Seiichi
Ohta, Makoto
Fukuda, Toshio
Arai, Fumihito
Najdovski, ZoranORCID iD for Najdovski, Zoran
Negoro, Makoto
Irie, Keiko
Journal name International journal of medical robotics and computer assisted surgery
Volume number 9
Issue number 2
Start page 213
End page 222
Total pages 10
Publisher Wiley
Place of publication London, England
Publication date 2013
ISSN 1478-5951
Keyword(s) cerebral aneurysm diagnosis
cerebral aneurysm prognosis
computational fluid dynamics
cyber-physical system
in vitro strain measurements for cerebral aneurysm
Summary Background: The development of new diagnostic technologies for cerebrovascular diseases requires an understanding of the mechanism behind the growth and rupture of cerebral aneurysms. To provide a comprehensive diagnosis and prognosis of this disease, it is desirable to evaluate wall shear stress, pressure, deformation and strain in the aneurysm region, based on information provided by medical imaging technologies. Methods: In this research, we propose a new cyber-physical system composed of in vitro dynamic strain experimental measurements and computational fluid dynamics (CFD) simulation for the diagnosis of cerebral aneurysms. A CFD simulation and a scaled-up membranous silicone model of a cerebral aneurysm were completed, based on patient-specific data recorded in August 2008. In vitro blood flow simulation was realized with the use of a specialized pump. A vision system was also developed to measure the strain at different regions on the model by way of pulsating blood flow circulating inside the model. Results: Experimental results show that distance and area strain maxima were larger near the aneurysm neck (0.042 and 0.052), followed by the aneurysm dome (0.023 and 0.04) and finally the main blood vessel section (0.01 and 0.014). These results were complemented by a CFD simulation for the addition of wall shear stress, oscillatory shear index and aneurysm formation index. Diagnosis results using imaging obtained in August 2008 are consistent with the monitored aneurysm growth in 2011. Conclusion: The presented study demonstrates a new experimental platform for measuring dynamic strain within cerebral aneurysms. This platform is also complemented by a CFD simulation for advanced diagnosis and prediction of the growth tendency of an aneurysm in endovascular surgery.
Language eng
DOI 10.1002/rcs.1487
Field of Research 100402 Medical Biotechnology Diagnostics (incl Biosensors)
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collection: Centre for Intelligent Systems Research
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