Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery

Wang, Yichao, Li, Puwang and Kong, Lingxue 2013, Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery, AAPS PharmSciTech, vol. 14, no. 2, pp. 585-592, doi: 10.1208/s12249-013-9943-3.

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Title Chitosan-modified PLGA nanoparticles with versatile surface for improved drug delivery
Author(s) Wang, Yichao
Li, Puwang
Kong, LingxueORCID iD for Kong, Lingxue
Journal name AAPS PharmSciTech
Volume number 14
Issue number 2
Start page 585
End page 592
Total pages 8
Publisher Springer
Place of publication Berlin, Germany
Publication date 2013
ISSN 1530-9932
Keyword(s) chitosan
drug delivery system
Summary Shortage of functional groups on surface of poly(lactide-co-glycolide) (PLGA)-based drug delivery carriers always hampers its wide applications such as passive targeting and conjugation with targeting molecules. In this research, PLGA nanoparticles were modified with chitosan through physical adsorption and chemical binding methods. The surface charges were regulated by altering pH value in chitosan solutions. After the introduction of chitosan, zeta potential of the PLGA nanoparticle surface changed from negative charge to positive one, making the drug carriers more affinity to cancer cells. Functional groups were compared between PLGA nanoparticles and chitosan-modified PLGA nanoparticles. Amine groups were exhibited on PLGA nanoparticle surface after the chitosan modification as confirmed by Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. The modified nanoparticles showed an initial burst release followed by a moderate and sustained release profile. Higher percentage of drugs from cumulative release can be achieved in the same prolonged time range. Therefore, PLGA nanoparticles modified by chitosan showed versatility of surface and a possible improvement in the efficacy of current PLGA-based drug delivery system.
Language eng
DOI 10.1208/s12249-013-9943-3
Field of Research 109999 Technology not elsewhere classified
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Institute for Frontier Materials
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