Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication

Das, Saurabh, Banquy, Xavier, Zappone, Bruno, Greene, George W., Jay, Gregory D. and Israelachvili, Jacob N. 2013, Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication, Biomacromolecules, vol. 14, no. 5, pp. 1669-1677.

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Title Synergistic interactions between grafted hyaluronic acid and lubricin provide enhanced wear protection and lubrication
Author(s) Das, Saurabh
Banquy, Xavier
Zappone, Bruno
Greene, George W.
Jay, Gregory D.
Israelachvili, Jacob N.
Journal name Biomacromolecules
Volume number 14
Issue number 5
Start page 1669
End page 1677
Total pages 9
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2013
ISSN 1525-7797
1526-4602
Summary Normal (e.g., adhesion) and lateral (friction) forces were measured between physisorbed and chemically grafted layers of hyaluronic acid (HA), an anionic polyelectrolyte in the presence of lubricin (Lub), a mucinous glycoprotein, on mica surfaces using a surface forces apparatus (SFA). This work demonstrates that high friction coefficients between the surfaces do not necessarily correlate with surface damage and that chemically grafted HA acts synergistically with Lub to provide friction reduction and enhanced wear protection to the surfaces. Surface immobilization of HA by grafting is necessary for such wear protection. Increasing the concentration of Lub enhances the threshold load that a chemically grafted HA surface can be subjected to before the onset of wear. Addition of Lub does not have any beneficial effect if HA is physisorbed to the mica surfaces. Damage occurs at loads less than 1 mN regardless of the amount of Lub, indicating that the molecules in the bulk play little or no role in protecting the surfaces from damage. Lub penetrates into the chemically bound HA to form a visco-elastic gel that reduces the coefficient of friction as well as boosts the strength of the surface against abrasive wear (damage).
Language eng
Field of Research 109999 Technology not elsewhere classified
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30055443

Document type: Journal Article
Collection: Institute for Frontier Materials
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