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Physical activity for cancer survivors : a meta-analysis of randomised controlled trials

Fong, Daniel Y.T., Ho, Judy W.C., Hui, Bryant P.H., Lee, Antoinette M., Macfarlane, Duncan J., Leung, Sharron S.K., Cerin, Ester, Chan, Wynnie Y.Y., Leung, Ivy P.F., Lam, Sharon H.S., Taylor, Aliki J. and Cheng, Kar-keung 2012, Physical activity for cancer survivors : a meta-analysis of randomised controlled trials, BMJ : British medical journal, vol. 344, no. 7844, pp. 1-14.

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Title Physical activity for cancer survivors : a meta-analysis of randomised controlled trials
Author(s) Fong, Daniel Y.T.
Ho, Judy W.C.
Hui, Bryant P.H.
Lee, Antoinette M.
Macfarlane, Duncan J.
Leung, Sharron S.K.
Cerin, Ester
Chan, Wynnie Y.Y.
Leung, Ivy P.F.
Lam, Sharon H.S.
Taylor, Aliki J.
Cheng, Kar-keung
Journal name BMJ : British medical journal
Volume number 344
Issue number 7844
Start page 1
End page 14
Total pages 14
Publisher BMJ Publishing Group
Place of publication London, England
Publication date 2012-02-18
ISSN 0959-535X
1468-5833
Keyword(s) aerobic exercise
article
bench press
body mass
body weight
breast cancer
Summary Objective To systematically evaluate the effects of physical activity in adult patients after completion of main treatment related to cancer. Design Meta-analysis of randomised controlled trials with data extraction and quality assessment performed independently by two researchers. Data sources Pubmed, CINAHL, and Google Scholar from the earliest possible year to September 2011. References from meta-analyses and reviews. Study selection Randomised controlled trials that assessed the effects of physical activity in adults who had completed their main cancer treatment, except hormonal treatment. Results There were 34 randomised controlled trials, of which 22 (65%) focused on patients with breast cancer, and 48 outcomes in our meta-analysis. Twenty two studies assessed aerobic exercise, and four also included resistance or strength training. The median duration of physical activity was 13 weeks (range 3-60 weeks). Most control groups were considered sedentary or were assigned no exercise. Based on studies on patients with breast cancer, physical activity was associated with improvements in insulin-like growth factor-I, bench press, leg press, fatigue, depression, and quality of life. When we combined studies on different types of cancer, we found significant improvements in body mass index (BMI), body weight, peak oxygen consumption, peak power output, distance walked in six minutes, right handgrip strength, and quality of life. Sources of study heterogeneity included age, study quality, study size, and type and duration of physical activity. Publication bias did not alter our conclusions. Conclusions Physical activity has positive effects on physiology, body composition, physical functions, psychological outcomes, and quality of life in patients after treatment for breast cancer. When patients with cancer other than breast cancer were also included, physical activity was associated with reduced BMI and body weight, increased peak oxygen consumption and peak power output, and improved quality of life.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, BMJ Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30055832

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.