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Multiple pharmacological interventions targeting cardiovascular disease risk factors in individuals with type 2 diabetes - systematic review Khalil, Hanan, McNamara, K and Pan, Y 2013, Multiple pharmacological interventions targeting cardiovascular disease risk factors in individuals with type 2 diabetes - systematic review, Journal of diabetes research & clinical metabolism, vol. 2, no. 9, pp. 1-7. Title Multiple pharmacological interventions targeting cardiovascular disease risk factors in individuals with type 2 diabetes - systematic review Author(s) Khalil, Hanan McNamara, K Pan, Y Journal name Journal of diabetes research & clinical metabolism Volume number 2 Issue number 9 Start page 1 End page 7 Publisher Herbert Publications Place of publication Bedfordshire, England Publication date 2013 ISSN 2050-0866 Keyword(s) cardiovascular risk factors diabetes mortality pharmacological interventions systematic review Summary Background: The use of pharmacological agents has been shown to slow down the progression of microvascular and macrovascular complications. Most clinical trials address one pharmacological intervention at a time. To date, only a few studies explored multi-factorial pharmacological interventions in T2DM individuals for preventing CVD related complications. Given the current therapeutic inertia in pharmacological management of CVD risk factors, it is important to establish the benefits of a more holistic approach. Therefore, the aim of this review is to assess the efficacy of multiple pharmacological interventions for cardiovascular diseases (CVD) risk factors with or without conventional care in reducing all cause mortality, CVD mortality, stroke and cardiovascular events among adults with type 2 diabetes. Current evidence fails to support the benefit of multiple pharmacological interventions on all cause mortality and death from cardiovascular causes. However, beneficial effects were seen on the reduction of the overall number of cardiovascular events and there were promising trends for secondary outcomes such as stroke, myocardial infarction, revascularisation and amputation. Language eng Field of Research 111799 Public Health and Health Services not elsewhere classified Socio Economic Objective 920499 Public Health (excl. Specific Population Health) not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal Persistent URL http://hdl.handle.net/10536/DRO/DU:30055886 Document type: Journal Article Collection: Population Health Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 11 Sep 2013, 15:25:40 EST Thu, 12 Sep 2013, 08:27:54 EST Thu, 12 Sep 2013, 14:41:36 EST Thu, 12 Sep 2013, 14:43:06 EST Thu, 12 Sep 2013, 14:44:12 EST Mon, 23 Sep 2013, 08:57:14 EST Filtered Full Access Statistics: 13 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Wed, 11 Sep 2013, 15:25:24 EST by Barb Lavelle

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