This project provides compelling evidence that the clusterin, COMMD1 and ApoE proteins function in the quality control of the essential copper-transport proteins ATP7A and ATP7B. This knowledge is significant because variations in the clusterin, COMMD1 or ApoE genes may explain the variability of patient symptoms in the copper-transport disorders, Menkes and Wilson diseases.
Field of Research
060199 Biochemistry and Cell Biology not elsewhere classified 060109 Proteomics and Intermolecular Interactions (excl Medical Proteomics)
Socio Economic Objective
970111 Expanding Knowledge in the Medical and Health Sciences
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