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Estimating nephron number in the developing kidney using the physical disector/fractionator combination

Cullen-McEwen, Luise A., Armitage, James A., Nyengaard, Jens R. and Bertram, John F. 2012, Estimating nephron number in the developing kidney using the physical disector/fractionator combination. In Michos, Odysse (ed), Kidney development: methods and protocols, Springer Science & Business Media, Dordrecht, The Netherlands, pp.109-119.

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Title Estimating nephron number in the developing kidney using the physical disector/fractionator combination
Author(s) Cullen-McEwen, Luise A.
Armitage, James A.
Nyengaard, Jens R.
Bertram, John F.
Title of book Kidney development: methods and protocols
Editor(s) Michos, Odysse
Publication date 2012
Series Methods in molecular biology 886
Chapter number 10
Total chapters 35
Start page 109
End page 119
Total pages 11
Publisher Springer Science & Business Media
Place of Publication Dordrecht, The Netherlands
Keyword(s) nephron endowment
nephron number
kidney development
stereology
disector
metanephros
Summary Over the last decade the development of new molecular biology tools, advanced microscopy, live imaging and systems biology approaches have revolutionized our conception of how embryonic development proceeds. One fundamental aspect of development biology is the concept of morphogenesis: understanding how a group of multipotent cells organize and differentiate into a complex organ. In Kidney Development: Methods and Protocols, expert researchers in the field detail different approaches to tackle kidney development. These approaches include culture and live imaging aspects of kidney development, analyzing the 3-dimensional aspects of branching morphogenesis as well as nephrogenesis, manipulation of the gene/protein expression during kidney development as well as in the adult kidney, and how to assess kidney malformation and disease. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Kidney Development: Methods and Protocols seeks to aid scientists in the further study of the process of morphogenesis which is fundamental important not only for studying developmental biology but also for regenerative medicine.
ISBN 1617798517
9781617798511
Language eng
Field of Research 110312 Nephrology and Urology
Socio Economic Objective 920119 Urogenital System and Disorders
HERDC Research category B1.1 Book chapter
Copyright notice ©2012, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30056687

Document type: Book Chapter
Collection: School of Medicine
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Created: Thu, 10 Oct 2013, 10:14:31 EST by Jane Moschetti

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