Skeletal muscle nitric oxide signalling and exercise: a focus on glucose metabolism

McConell, Glenn K, Rattigan, Steven, Lee-Young, Robert, Wadley, Glenn D and Merry, Troy 2012, Skeletal muscle nitric oxide signalling and exercise: a focus on glucose metabolism, American journal of physiology, endocrinology and metabolism, vol. 303, no. 3, pp. E301-E307, doi: 10.1152/ajpendo.00667.2011.

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Title Skeletal muscle nitric oxide signalling and exercise: a focus on glucose metabolism
Author(s) McConell, Glenn K
Rattigan, Steven
Lee-Young, Robert
Wadley, Glenn DORCID iD for Wadley, Glenn D
Merry, Troy
Journal name American journal of physiology, endocrinology and metabolism
Volume number 303
Issue number 3
Start page E301
End page E307
Total pages 7
Publisher American Physiological Society
Place of publication Bethesda, Maryland
Publication date 2012-08
ISSN 0193-1849
Keyword(s) nitric oxide
glucose uptake
blood flow
oxygen consumption
5=- adenosine monophosphate-activated protein kinase
reactive oxygen species
mitochondrial biogenesis
Summary Nitric oxide (NO) is an important vasodilator and regulator in the cardiovascular system, and this link was the subject of a Nobel prize in 1998. However, NO also plays many other regulatory roles, including thrombosis, immune function, neural activity, and gastrointestinal function. Low concentrations of NO are thought to have important signaling effects. In contrast, high concentrations of NO can interact with reactive oxygen species, causing damage to cells and cellular components.

A less-recognized site of NO production is within skeletal muscle, where small increases are thought to have beneficial effects such as regulating glucose uptake and possibly blood flow, but higher levels of production are thought to lead to deleterious effects such as an association with insulin resistance.

This review will discuss the role of NO in skeletal muscle during and following exercise, including in mitochondrial biogenesis, muscle efficiency, and blood flow with a particular focus on its potential role in regulating skeletal muscle glucose uptake during exercise.
Language eng
DOI 10.1152/ajpendo.00667.2011
Field of Research 110602 Exercise Physiology
111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, American Physiological Society
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Mon, 21 Oct 2013, 11:29:54 EST by Glenn Wadley

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