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Effect of pregnancy for females born small on later life metabolic disease risk

Tran, Melanie, Gallo, Linda A., Wadley, Glenn D., Jefferies, Andrew J., Moritz, Karen M. and Wlodek, Mary E. 2012, Effect of pregnancy for females born small on later life metabolic disease risk, PLOS ONE, vol. 7, no. 9, Article: e45188, pp. 1-8.

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Title Effect of pregnancy for females born small on later life metabolic disease risk
Author(s) Tran, Melanie
Gallo, Linda A.
Wadley, Glenn D.
Jefferies, Andrew J.
Moritz, Karen M.
Wlodek, Mary E.
Journal name PLOS ONE
Volume number 7
Issue number 9
Season Article: e45188
Start page 1
End page 8
Total pages 8
Publisher Public Library of Science
Place of publication San Francisco, California
Publication date 2012-09
ISSN 1932-6203
Keyword(s) animal experiment
animal tissue
birth weight
female
glucose tolerance
glycogen liver test
growth disorder
insulin sensitivity
placenta insufficiency
pancreas insufficiency
Summary There is a strong inverse relationship between a females own birth weight and her subsequent risk for gestational diabetes with increased risk of developing diabetes later in life. We have shown that growth restricted females develop loss of glucose tolerance during late pregnancy with normal pancreatic function. 

The aim of this study was to determine whether growth restricted females develop long-term impairment of metabolic control after an adverse pregnancy adaptation. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) in late pregnancy (E18) in F0 female rats. F1 Control and Restricted female offspring were mated with normal males and allowed to deliver (termed Ex-Pregnant). Age-matched Control and Restricted Virgins were also studied and glucose tolerance and insulin secretion were determined. Pancreatic morphology and hepatic glycogen and triacylglycerol content were quantified respectively.

Restricted females were born lighter than Control and remained lighter at all time points studied (p<0.05). Glucose tolerance, first phase insulin secretion and liver glycogen and triacylglycerol content were not different across groups, with no changes in β-cell mass. Second phase insulin secretion was reduced in Restricted Virgins (-34%, p<0.05) compared to Control Virgins, suggestive of enhanced peripheral insulin sensitivity but this was lost after pregnancy. Growth restriction was associated with enhanced basal hepatic insulin sensitivity, which may provide compensatory benefits to prevent adverse metabolic outcomes often associated with being born small. A prior pregnancy was associated with reduced hepatic insulin sensitivity with effects more pronounced in Controls than Restricted.

Our data suggests that pregnancy ameliorates the enhanced peripheral insulin sensitivity in growth restricted females and has deleterious effects for hepatic insulin sensitivity, regardless of maternal birth weight.
Language eng
Field of Research 111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920104 Diabetes
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Public Library of Science (PLOS)
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057014

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Created: Mon, 21 Oct 2013, 11:36:21 EST by Glenn Wadley

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.