Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney

Ellery, Stacey J., Ireland, Zoe, Kett, Michelle M., Snow, Rod, Walker, David W. and Dickinson, Hayley 2013, Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney, Pediatric research, vol. 73, no. 2, pp. 201-208.

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Title Creatine pretreatment prevents birth asphyxia–induced injury of the newborn spiny mouse kidney
Author(s) Ellery, Stacey J.
Ireland, Zoe
Kett, Michelle M.
Snow, Rod
Walker, David W.
Dickinson, Hayley
Journal name Pediatric research
Volume number 73
Issue number 2
Start page 201
End page 208
Total pages 8
Publisher Nature Publishing Group
Place of publication New York, N.Y.
Publication date 2013-02
ISSN 0031-3998
1530-0447
Keyword(s) creatinine
nephrin
neutrophil gelatinase associated lipocalin
acute kidney failure
kidney injury
diet supplementation
birth asphyxia
Summary Background:
Acute kidney injury (AKI) is a major complication for infants following an asphyxic insult at birth. We aimed to determine if kidney structure and function were affected in an animal model of birth asphyxia and if maternal dietary creatine supplementation could provide an energy reserve to the fetal kidney, maintaining cellular respiration during asphyxia and preventing AKI.

Methods:
Pregnant spiny mice were maintained on normal chow or chow supplemented with creatine from day 20 gestation. On day 38 (term ~39 d), pups were delivered by cesarean section (c-section) or subjected to intrauterine asphyxia. Twenty-four hours after insult, kidneys were collected for histological or molecular analysis. Urine and plasma were also collected for biochemical analysis.

Results:
AKI was evident at 24 h after birth asphyxia, with a higher incidence of shrunken glomeruli (P < 0.02), disturbance to tubular arrangement, tubular dilatation, a twofold increase (P < 0.02) in expression of Ngal (early marker of kidney injury), and decreased expression of the podocyte differentiation marker nephrin. Maternal creatine supplementation prevented the glomerular and tubular abnormalities observed in the kidney at 24 h and the increased expression of Ngal.

Conclusion:
Maternal creatine supplementation may prove useful in ameliorating kidney injury associated with birth asphyxia.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1 Refereed article in a scholarly journal
HERDC collection year 2013
Copyright notice ©2013, Nature Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057034

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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