Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse

Dickinson, Hayley, Ireland, Zoe J., La Rosa, Domenic A., O'Connell, Bree A., Ellery, Stacey, Snow, Rod and Walker, David W. 2013, Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse, Reproductive sciences, vol. 20, no. 9, pp. 1096-1102.

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Title Maternal dietary creatine supplementation does not alter the capacity for creatine synthesis in the newborn spiny mouse
Author(s) Dickinson, Hayley
Ireland, Zoe J.
La Rosa, Domenic A.
O'Connell, Bree A.
Ellery, Stacey
Snow, Rod
Walker, David W.
Journal name Reproductive sciences
Volume number 20
Issue number 9
Start page 1096
End page 1102
Total pages 7
Publisher Sage Publications
Place of publication Thousand Oaks, California
Publication date 2013-09
ISSN 1933-7191
1933-7205
Keyword(s) maternal creatine supplementation
creatine synthesis enzymes
creatine transporter
Summary We have previously reported that maternal creatine supplementation protects the neonate from hypoxic injury. Here, we investigated whether maternal creatine supplementation altered expression of the creatine synthesis enzymes (arginine:glycine amidinotransferase [AGAT], guanidinoaceteate methyltransferase [GAMT]) and the creatine transporter (solute carrier family 6 [neurotransmitter transporter, creatine] member 8: SLC6A8) in the term offspring. Pregnant spiny mice were fed a 5% creatine monohydrate diet from midgestation (day 20) to term (39 days). Placentas and neonatal kidney, liver, heart, and brain collected at 24 hours of age underwent quantitative polymerase chain reaction and Western blot analysis. Maternal creatine had no effect on the expression of AGAT and GAMT in neonatal kidney and liver, but mRNA expression of AGAT in brain tissues was significantly decreased in both male and female neonates born to mothers who were fed the creatine diet. SLC6A8 expression was not affected by maternal dietary creatine loading in any tissues. Maternal dietary creatine supplementation from midgestation in the spiny mouse did not alter the capacity for creatine synthesis or transport.
Language eng
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Sage Publishing
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057038

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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