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Lipidomic profiling of chylomicron triacylglycerols in response to high fat meals

Bonham, Maxine P., Linderborg, Kaisa M., Dordevic, Aimee, Larsen, Amy E., Nguo, Kay, Weir, Jacquelyn M., Gran, Petra, Luotonen, Marika K., Meikle, Peter J., Cameron-Smith, David, Kallio, Heikki P. T. and Sinclair, Andrew J. 2013, Lipidomic profiling of chylomicron triacylglycerols in response to high fat meals, Lipids, vol. 48, pp. 39-50, doi: 10.1007/s11745-012-3735-5.

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Title Lipidomic profiling of chylomicron triacylglycerols in response to high fat meals
Author(s) Bonham, Maxine P.
Linderborg, Kaisa M.
Dordevic, Aimee
Larsen, Amy E.
Nguo, Kay
Weir, Jacquelyn M.
Gran, Petra
Luotonen, Marika K.
Meikle, Peter J.
Cameron-Smith, David
Kallio, Heikki P. T.
Sinclair, Andrew J.
Journal name Lipids
Volume number 48
Start page 39
End page 50
Total pages 12
Publisher Springer Science & Business Media
Place of publication Dordrecht, The Netherlands
Publication date 2013-01
ISSN 0024-4201
Keyword(s) chylomicron
lipid metabolism
metabolic syndrome
Summary Using lipidomic methodologies the impact that meal lipid composition and metabolic syndrome (MetS) exerts on the postprandial chylomicron triacylglycerol (TAG) response was examined. Males (9 control; 11 MetS) participated in a randomised crossover trial ingesting two high fat breakfast meals composed of either dairy-based foods or vegetable oil-based foods. The postprandial lipidomic molecular composition of the TAG in the chylomicron-rich (CM) fraction was analysed with tandem mass spectrometry coupled with liquid chromatography to profile CM TAG species and targeted TAG regioisomers. Postprandial CM TAG concentrations were significantly lower after the dairy-based foods compared with the vegetable oil-based foods for both control and MetS subjects. The CM TAG response to the ingested meals involved both significant and differential depletion of TAG species containing shorter-and medium-chain fatty acids (FA) and enrichment of TAG molecular species containing C16 and C18 saturated, monounsaturated and diunsaturated FA. Furthermore, there were significant changes in the TAG species between the food TAG and CM TAG and between the 3- and 5-h postprandial samples for the CM TAG regioisomers. Unexpectedly, the postprandial CM TAG concentration and CM TAG lipidomic responses did not differ between the control and MetS subjects. Lipidomic analysing of CM TAG molecular species revealed dynamic changes in the molecular species of CM TAG during the postprandial phase suggesting either preferential CM TAG species formation and/or clearance.
Language eng
DOI 10.1007/s11745-012-3735-5
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Springer
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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Created: Tue, 22 Oct 2013, 11:33:11 EST by Andrew Sinclair

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