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Trafficking of hepatitis C virus core protein during virus particle assembly

Counihan, Natalie A., Rawlinson, Stephen M. and Lindenbach, Brett D. 2011, Trafficking of hepatitis C virus core protein during virus particle assembly, PLoS pathogens, vol. 7, no. 10, pp. 1-14, doi: 10.1371/journal.ppat.1002302.

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Title Trafficking of hepatitis C virus core protein during virus particle assembly
Author(s) Counihan, Natalie A.
Rawlinson, Stephen M.
Lindenbach, Brett D.
Journal name PLoS pathogens
Volume number 7
Issue number 10
Article ID e1002302
Start page 1
End page 14
Total pages 14
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2011-10
ISSN 1553-7366
1553-7374
Keyword(s) hepatitis C virus (HCV) core protein
virus particle assembly
core trafficking
Summary Hepatitis C virus (HCV) core protein is directed to the surface of lipid droplets (LD), a step that is essential for infectious virus production. However, the process by which core is recruited from LD into nascent virus particles is not well understood. To investigate the kinetics of core trafficking, we developed methods to image functional core protein in live, virus-producing cells. During the peak of virus assembly, core formed polarized caps on large, immotile LDs, adjacent to putative sites of assembly. In addition, LD-independent, motile puncta of core were found to traffic along microtubules. Importantly, core was recruited from LDs into these puncta, and interaction between the viral NS2 and NS3-4A proteins was essential for this recruitment process. These data reveal new aspects of core trafficking and identify a novel role for viral nonstructural proteins in virus particle assembly.
Language eng
DOI 10.1371/journal.ppat.1002302
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057478

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.