The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence

Nunes, Sandra, Vargas, Herber, Prado, Eduardo, Barbosa, Decio, Picoli de Melo, Luiz, Moylan, Steven, Dodd, Seetal and Berk, Michael 2013, The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence, Neuroscience and biobehavioral reviews, vol. 37, pp. 1336-1345.

Attached Files
Name Description MIMEType Size Downloads

Title The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence
Author(s) Nunes, Sandra
Vargas, Herber
Prado, Eduardo
Barbosa, Decio
Picoli de Melo, Luiz
Moylan, Steven
Dodd, Seetal
Berk, Michael
Journal name Neuroscience and biobehavioral reviews
Volume number 37
Start page 1336
End page 1345
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2013-09
ISSN 0149-7634
1873-7528
Keyword(s) dependence
depression
inflammation
nicotine
oxidative stress
Summary Nicotine dependence is common in people with mood disorders; however the operative pathways are not well understood. This paper reviews the contribution of inflammation and oxidative stress pathways to the co-association of depressive disorder and nicotine dependence, including increased levels of pro-inflammatory cytokines, increased acute phase proteins, decreased levels of antioxidants and increased oxidative stress. These could be some of the potential pathophysiological mechanisms involved in neuroprogression. The shared inflammatory and oxidative stress pathways by which smoking may increase the risk for development of depressive disorders are in part mediated by increased levels of pro-inflammatory cytokines, diverse neurotransmitter systems, activation the hypothalamic-pituitary-adrenal (HPA) axis, microglial activation, increased production of oxidative stress and decreased levels of antioxidants. Depressive disorder and nicotine dependence are additionally linked imbalance between neuroprotective and neurodegenerative metabolites in the kynurenine pathway that contribute to neuroprogression. These pathways provide a mechanistic framework for understanding the interaction between nicotine dependence and depressive disorder.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057563

Document type: Journal Article
Collection: School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 3 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 74 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Tue, 12 Nov 2013, 10:13:08 EST by Jane Moschetti

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.