Human neuronal cells : epigenetic aspects

Kukucka, Jessica, Wyllie, Tessa, Read, Justin, Mahoney, Lauren and Suphioglu, Cenk 2013, Human neuronal cells : epigenetic aspects, Biomolecular concepts, vol. 4, no. 4, pp. 319-333.

Attached Files
Name Description MIMEType Size Downloads

Title Human neuronal cells : epigenetic aspects
Author(s) Kukucka, Jessica
Wyllie, Tessa
Read, Justin
Mahoney, Lauren
Suphioglu, Cenk
Journal name Biomolecular concepts
Volume number 4
Issue number 4
Start page 319
End page 333
Total pages 15
Publisher Walter de Gruyter GmbH & Co. KG
Place of publication Berlin, Germany
Publication date 2013
ISSN 1868-5021
Keyword(s) acetylation
Alzheimer's disease
deacetylation
gene expression
neuroprotection
neurotoxicity
Summary Histone acetyltransferases (HATs) and histone deacetylases (HDACs) promote histone posttranslational modifications, which lead to an epigenetic alteration in gene expression. Aberrant regulation of HATs and HDACs in neuronal cells results in pathological consequences such as neurodegeneration. Alzheimer's disease is the most common neurodegenerative disease of the brain, which has devastating effects on patients and loved ones. The use of pan-HDAC inhibitors has shown great therapeutic promise in ameliorating neurodegenerative ailments. Recent evidence has emerged suggesting that certain deacetylases mediate neurotoxicity, whereas others provide neuroprotection. Therefore, the inhibition of certain isoforms to alleviate neurodegenerative manifestations has now become the focus of studies. In this review, we aimed to discuss and summarize some of the most recent and promising findings of HAT and HDAC functions in neurodegenerative diseases.
Language eng
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Walter de Gruyter GmbH & Co. KG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057737

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Access Statistics: 20 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Tue, 12 Nov 2013, 14:47:42 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.