A low power micro deep brain stimulation device for murine preclinical research

Kouzani, Abbas Z., Abulseoud, Osama A., Tye, Susannah J., Hosain, Md Kamal and Berk, Michael 2013, A low power micro deep brain stimulation device for murine preclinical research, IEEE journal of translational engineering in health and medicine, vol. 1, pp. 1-9, doi: 10.1109/JTEHM.2013.2264093.

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Title A low power micro deep brain stimulation device for murine preclinical research
Author(s) Kouzani, Abbas Z.ORCID iD for Kouzani, Abbas Z. orcid.org/0000-0002-6292-1214
Abulseoud, Osama A.
Tye, Susannah J.
Hosain, Md Kamal
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Journal name IEEE journal of translational engineering in health and medicine
Volume number 1
Start page 1
End page 9
Total pages 9
Publisher IEEE
Place of publication Piscataway, N.J.
Publication date 2013
ISSN 2168-2372
Keyword(s) deep brain stimulation
long-term stimulation
low-power lightweight device
stimulation current pulse
Summary Deep brain stimulation has emerged as an effective medical procedure that has therapeutic efficacy in a number of neuropsychiatric disorders. Preclinical research involving laboratory animals is being conducted to study the principles, mechanisms, and therapeutic effects of deep brain stimulation. A bottleneck is, however, the lack of deep brain stimulation devices that enable long term brain stimulation in freely moving laboratory animals. Most of the existing devices employ complex circuitry, and are thus bulky. These devices are usually connected to the electrode that is implanted into the animal brain using long fixed wires. In long term behavioral trials, however, laboratory animals often need to continuously receive brain stimulation for days without interruption, which is difficult with existing technology. This paper presents a low power and lightweight portable microdeep brain stimulation device for laboratory animals. Three different configurations of the device are presented as follows: 1) single piece head mountable; 2) single piece back mountable; and 3) two piece back mountable. The device can be easily carried by the animal during the course of a clinical trial, and that it can produce non-stop stimulation current pulses of desired characteristics for over 12 days on a single battery. It employs passive charge balancing to minimize undesirable effects on the target tissue. The results of bench, in-vitro, and in-vivo tests to evaluate the performance of the device are presented.
Language eng
DOI 10.1109/JTEHM.2013.2264093
Field of Research 090304 Medical Devices
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057793

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