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Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration

Mushahary, Dolly, Sravanthi, Ragamouni, Li, Yuncang, Kumar, Mahesh J., Harishankar, Nemani, Hodgson, Peter D., Wen, Cuie and Pande, Gopal 2013, Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration, International journal of nanomedicine, vol. 8, no. 1, pp. 2887-2902.

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Title Zirconium, calcium, and strontium contents in magnesium based biodegradable alloys modulate the efficiency of implant-induced osseointegration
Author(s) Mushahary, Dolly
Sravanthi, Ragamouni
Li, Yuncang
Kumar, Mahesh J.
Harishankar, Nemani
Hodgson, Peter D.
Wen, Cuie
Pande, Gopal
Journal name International journal of nanomedicine
Volume number 8
Issue number 1
Start page 2887
End page 2902
Total pages 16
Publisher Dove Medical Press
Place of publication Auckland, New Zealand
Publication date 2013
ISSN 1178-2013
Keyword(s) osteoblasts
bone mineralization
corrosion
osseointegration
surface energy
peri-implant
Summary Development of new biodegradable implants and devices is necessary to meet the increasing needs of regenerative orthopedic procedures. An important consideration while formulating new implant materials is that they should physicochemically and biologically mimic bone-like properties. In earlier studies, we have developed and characterized magnesium based biodegradable alloys, in particular magnesium-zirconium (Mg-Zr) alloys. Here we have reported the biological properties of four Mg-Zr alloys containing different quantities of strontium or calcium. The alloys were implanted in small cavities made in femur bones of New Zealand White rabbits, and the quantitative and qualitative assessments of newly induced bone tissue were carried out. A total of 30 experimental animals, three for each implant type, were studied, and bone induction was assessed by histological, immunohistochemical and radiological methods; cavities in the femurs with no implants and observed for the same period of time were kept as controls. Our results showed that Mg-Zr alloys containing appropriate quantities of strontium were more efficient in inducing good quality mineralized bone than other alloys. Our results have been discussed in the context of physicochemical and biological properties of the alloys, and they could be very useful in determining the nature of future generations of biodegradable orthopedic implants.
Language eng
Field of Research 099999 Engineering not elsewhere classified
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Dove Medical Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30057808

Document type: Journal Article
Collections: Institute for Frontier Materials
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