Cardiac adaptation to endurance exercise in rats

Fenning, Andrew, Harrison, Glenn, Dwyer, Dan, Rose'Meyer, Roselyn and Brown, Lindsay 2003, Cardiac adaptation to endurance exercise in rats, Molecular and cellular biochemistry, vol. 251, no. 1-2, pp. 51-59, doi: 10.1023/A:1025465412329.

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Title Cardiac adaptation to endurance exercise in rats
Author(s) Fenning, Andrew
Harrison, Glenn
Dwyer, DanORCID iD for Dwyer, Dan orcid.org/0000-0002-8177-7262
Rose'Meyer, Roselyn
Brown, Lindsay
Journal name Molecular and cellular biochemistry
Volume number 251
Issue number 1-2
Start page 51
End page 59
Total pages 9
Publisher Springer
Place of publication Dordrecht, The Netherlands
Publication date 2003-09
ISSN 0300-8177
1573-4919
Keyword(s) physiological hypertrophy
rat
endurance exercise
myocardial energy metabolism
Summary Endurance exercise is widely assumed to improve cardiac function in humans. This project has determined cardiac function following endurance exercise for 6 (n = 30) or 12 (n = 25) weeks in male Wistar rats (8 weeks old). The exercise protocol was 30 min/day at 0.8 km/h for 5 days/week with an endurance test on the 6th day by running at 1.2 km/h until exhaustion. Exercise endurance increased by 318% after 6 weeks and 609% after 12 weeks. Heart weight/kg body weight increased by 10.2% after 6 weeks and 24.1% after 12 weeks. Echocardiography after 12 weeks showed increases in left ventricular internal diameter in diastole (6.39 ± 0.32 to 7.90 ± 0.17 mm), systolic volume (49 ± 7 to 83 ± 11 μl) and cardiac output (75 ± 3 to 107 ± 8 ml/min) but not left wall thickness in diastole (1.74 ± 0.07 to 1.80 ± 0.06 mm). Isolated Langendorff hearts from trained rats displayed decreased left ventricular myocardial stiffness (22 ± 1.1 to 19.1 ± 0.3) and reduced purine efflux during pacing-induced workload increases. 31P-NMR spectroscopy in isolated hearts from trained rats showed decreased PCr and PCr/ATP ratios with increased creatine, AMP and ADP concentrations. Thus, this endurance exercise protocol resulted in physiological hypertrophy while maintaining or improving cardiac function.
Language eng
DOI 10.1023/A:1025465412329
Field of Research 110602 Exercise Physiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2003, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30058704

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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Created: Mon, 02 Dec 2013, 12:04:33 EST by Dan Dwyer

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