Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist

Dwyer, Dan and Flynn, John 2002, Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist, Experimental physiology, vol. 87, no. 1, pp. 83-89, doi: 10.1113/eph8702176.

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Title Short term aerobic exercise training in young males does not alter sensitivity to a central serotonin agonist
Author(s) Dwyer, DanORCID iD for Dwyer, Dan orcid.org/0000-0002-8177-7262
Flynn, John
Journal name Experimental physiology
Volume number 87
Issue number 1
Start page 83
End page 89
Total pages 7
Publisher Wiley
Place of publication London, England
Publication date 2002-01
ISSN 0958-0670
1469-445X
Keyword(s) Aerobic exercise
Young males
Central serotonin agonist
Summary An increase in the concentration of serotonin in the brain has been shown to cause fatigue during exercise in humans and experimental animals. This type of fatigue is referred to as central fatigue and is likely to be mediated by the concentration of serotonin as well as serotonin receptor sensitivity. Serotonin (5-HT) receptor antagonism in humans and experimental animals has been shown to improve endurance performance. A previous report has shown decreased receptor sensitivity in athletes compared to sedentary controls. It is unclear whether this is due to a training adaptation or if individuals are predisposed to enhanced athletic performance due to their inherent decreased receptor sensitivity. The present study investigated changes in 5-HT receptor sensitivity in response to aerobic exercise. Subjects completed 3 × 30 min of stationary cycling at 70% of their peak aerobic power (V̇O2,peak) for 9 weeks. Serotonin receptor sensitivity was assessed indirectly by measuring the neuroendocrine response following administration of a serotonin agonist (buspirone hydrochloride). The neuroendocrine response following administration of a placebo was also investigated in a blind crossover design. A group of sedentary control subjects was also recruited to control for seasonal variations in central receptor sensitivity. The training caused a significant increase in V̇O2,peak (3.1 ± 0.16 to 3.6 ± 0.15 l min−1, P < 0.05) and endurance capacity (93 ± 8 to 168 ± 11 min, P < 0.05), but there was no change (P > 0.05) in the neuroendocrine response in the presence of a serotonin agonist. However, one-quarter of the subjects in the training group demonstrated decreases in receptor sensitivity. These results suggest that despite increases in V̇O2,peak and endurance performance, there was no measurable change in 5-HT receptor sensitivity in the presence of a serotonin agonist. In addition, it is possible that changes in receptor sensitivity may take longer to occur, that the training stimulus used in the present investigation was inadequate and/or that changes occurred in receptor subtypes that were not probed by the agonist used in the present investigation.
Language eng
DOI 10.1113/eph8702176
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, Wiley
Persistent URL http://hdl.handle.net/10536/DRO/DU:30058706

Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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Created: Mon, 02 Dec 2013, 12:16:02 EST by Dan Dwyer

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