Formulation and simulation of a 3D mechanical model of embryos for microinjection

Asgari, Marzieh, Abdi, Hamid, Lim, Chee Peng and Nahavandi, Saeid 2013, Formulation and simulation of a 3D mechanical model of embryos for microinjection, in SMC 2013 : Proceedings of the 2013 IEEE International Conference on Systems, Man and Cybernetics, IEEE, Piscataway, N.J., pp. 2219-2224.

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Title Formulation and simulation of a 3D mechanical model of embryos for microinjection
Author(s) Asgari, MarziehORCID iD for Asgari, Marzieh orcid.org/0000-0001-7183-7156
Abdi, HamidORCID iD for Abdi, Hamid orcid.org/0000-0001-6597-7136
Lim, Chee PengORCID iD for Lim, Chee Peng orcid.org/0000-0003-4191-9083
Nahavandi, SaeidORCID iD for Nahavandi, Saeid orcid.org/0000-0002-0360-5270
Conference name IEEE Systems, Man and Cybernetics. Conference (2013 : Manchester, England)
Conference location Manchester, England
Conference dates 13-16 Oct. 2013
Title of proceedings SMC 2013 : Proceedings of the 2013 IEEE International Conference on Systems, Man and Cybernetics
Editor(s) [Unknown]
Publication date 2013
Conference series IEEE Systems, Man and Cybernetics Conference
Start page 2219
End page 2224
Total pages 6
Publisher IEEE
Place of publication Piscataway, N.J.
Keyword(s) component
cell modelling
indentation force and deformation
zebrafish egg microinjection
Summary The understanding of cell manipulation, for example in microinjection, requires an accurate model of the cells. Motivated by this important requirement, a 3D particlebased mechanical model is derived for simulating the deformation of the fish egg membrane and the corresponding cellular forces during microrobotic cell injection. The model is formulated based on the kinematic and dynamic of spring- damper configuration with multi-particle joints considering the visco-elastic fluidic properties. It simulates the indentation force feedback as well as cell visual deformation during microinjection. A preliminary simulation study is conducted with different parameter configurations. The results indicate that the proposed particle-based model is able to provide similar deformation profiles as observed from a real microinjection experiment of the zebrafish embryo published in the literature. As a generic modelling approach is adopted, the proposed model also has the potential in applications with different types of manipulation such as micropipette cell aspiration.
Language eng
Field of Research 091307 Numerical Modelling and Mechanical Characterisation
Socio Economic Objective 970109 Expanding Knowledge in Engineering
HERDC Research category E1 Full written paper - refereed
Copyright notice ©2013, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30058836

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