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Aptamers as theranostic agents: modifications, serum stability and functionalisation

Shigdar, Sarah, Macdonald, Joanna, O'Connor, Michael, Wang, Tao, Xiang, Dongxi, Al.Shamaileh, Hadi, Qiao, Liang, Wei, Ming, Zhou, Shu-Feng, Zhu, Yimin, Kong, Lingxue, Bhattacharya, Santanu, Li, ChunGuang and Duan, Wei 2013, Aptamers as theranostic agents: modifications, serum stability and functionalisation, Sensors, vol. 13, no. 10, pp. 13624-13637.

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Title Aptamers as theranostic agents: modifications, serum stability and functionalisation
Author(s) Shigdar, Sarah
Macdonald, Joanna
O'Connor, Michael
Wang, Tao
Xiang, Dongxi
Al.Shamaileh, Hadi
Qiao, Liang
Wei, Ming
Zhou, Shu-Feng
Zhu, Yimin
Kong, Lingxue
Bhattacharya, Santanu
Li, ChunGuang
Duan, Wei
Journal name Sensors
Volume number 13
Issue number 10
Start page 13624
End page 13637
Total pages 14
Publisher M D P I AG
Place of publication Basel, Switzerland
Publication date 2013-10
ISSN 1424-8239
1424-8220
Keyword(s) aptamer
SELEX
cancer
diagnostics
locked nucleic acid
unlocked nucleic acid
Summary Aptamers, and the selection process known as Systematic Evolution of Ligands by Exponential Enrichment (SELEX) used to generate them, were first described more than twenty years ago. Since then, there have been numerous modifications to the selectionprocedures. This review discusses the use of modified bases as a means of enhancing serum stability and producing effective therapeutic tools, as well as functionalising these nucleic acids to be used as potential diagnostic agents.
Language eng
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, M D P I AG
Persistent URL http://hdl.handle.net/10536/DRO/DU:30059488

Document type: Journal Article
Collections: School of Medicine
Institute for Frontier Materials
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.