Evolution of the JAK-STAT pathway

Liongue, Clifford and Ward, Alister 2013, Evolution of the JAK-STAT pathway, JAK-STAT, vol. 2, no. 1, pp. e22756-1-e22756-8.

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Title Evolution of the JAK-STAT pathway
Author(s) Liongue, Clifford
Ward, Alister
Journal name JAK-STAT
Volume number 2
Issue number 1
Start page e22756-1
End page e22756-8
Total pages 8
Publisher Landes Bioscience
Place of publication Austin, Tex.
Publication date 2013
ISSN 2162-3996
Keyword(s) JAK
Evolution
SHP
SOCS
STAT
Summary The JAK-STAT pathway represents a finely tuned orchestra capable of rapidly facilitating an exquisite symphony of responses from a complex array of extracellular signals. This review explores the evolution of the JAK-STAT pathway: the origins of the individual domains from which it is constructed, the formation of individual components from these basic building blocks, the assembly of the components into a functional pathway, and the subsequent reiteration of this basic template to fulfill a variety of roles downstream of cytokine receptors.
Language eng
Field of Research 060111 Signal Transduction
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Landes Bioscience
Persistent URL http://hdl.handle.net/10536/DRO/DU:30059495

Document type: Journal Article
Collection: School of Medicine
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