Antidepressant pharmacogenetics

Singh, Ajeet B, Bousman, Chad A, Ng, Chee and Berk, Michael 2013, Antidepressant pharmacogenetics, Current Opinion in Psychiatry, vol. 27, no. 1, pp. 43-51.

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Title Antidepressant pharmacogenetics
Author(s) Singh, Ajeet B
Bousman, Chad A
Ng, Chee
Berk, Michael
Journal name Current Opinion in Psychiatry
Volume number 27
Issue number 1
Start page 43
End page 51
Total pages 9
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, PA
Publication date 2013
ISSN 0951-7367
Keyword(s) Antidepressants
Pharmacogenomics
Pharmacogenetics
Major depression
Biomarkers
Summary Purpose of review: This article reviews recent literature published over the period March 2012–August 2013 on antidepressant pharmacogenetics, with a focus on clinical translation and methodological challenges.

Recent findings: Recently, various polymorphisms associated with differential antidepressant efficacy, tolerability, and safety have emerged in association studies, but mixed findings, limited effect sizes, and poor control of confounders have prevented findings translating to practice. Although promising steps have been made, empirically robust clinically translatable pharmacogenetic tests are not yet established. The complex neurobiology of major depressive disorder (MDD) together with the evolving understanding of genetic processes present research challenges for clinical translation.

Summary: Early reports of clinical utility are published. The current evidence base for antidepressant pharmacogenetics is, however, not yet empirically robust enough to inform routine prescribing guidelines. Over the coming years, genetically guided versus unguided trials will help determine if antidepressant pharmacogenetics merits more widespread application.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060277

Document type: Journal Article
Collection: School of Medicine
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