Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15

Dancevic, Carolyn M, Fraser, Fiona W, Smith, Adam D, Stupka, Nicole, Ward, Alister C and McCulloch, Daniel R 2013, Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15, Journal of Biological Chemistry, vol. 288, no. 52, pp. 37267-37276.

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Title Biosynthesis and expression of a disintegrin-like and metalloproteinase domain with thrombospondin-1 repeats-15
Author(s) Dancevic, Carolyn M
Fraser, Fiona W
Smith, Adam D
Stupka, Nicole
Ward, Alister C
McCulloch, Daniel R
Journal name Journal of Biological Chemistry
Volume number 288
Issue number 52
Start page 37267
End page 37276
Total pages 10
Publisher American Society for Biochemistry and Molecular Biology
Place of publication Rockville, Md.
Publication date 2013
ISSN 0021-9258
Keyword(s) Biosynthesis
Summary Background
ADAMTS proteoglycanases show proteolytic activity toward versican and other proteoglycans.

Results
ADAMTS15, which cleaves versican, is expressed during early cardiac development and during musculoskeletal development.

Conclusion
With unique and overlapping biological properties, ADAMTS15 is likely to have cooperative roles with other members of the ADAMTS proteoglycanase clade.

Significance
Versican cleavage has profound effects on developmental morphogenesis and regulates cancer cell behavior.
Language eng
Field of Research 111603 Systems Physiology
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, American Society for Biochemistry and Molecular Biology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060298

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 06 Feb 2014, 14:31:17 EST by Jane Moschetti

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