A systematic review and meta-analysis of diabetes and risk of physical disability and functional impairment - protocol

Wong, Evelyn, Backholer, Kathryn, Harding, Jessica, Gearon, Emma, Stevenson, Christopher, Freak-Poli, Rosanne and Peeters, Anna 2012, A systematic review and meta-analysis of diabetes and risk of physical disability and functional impairment - protocol, Systematic Reviews, vol. 1, no. 1, Article 47, pp. 1-4.

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Title A systematic review and meta-analysis of diabetes and risk of physical disability and functional impairment - protocol
Author(s) Wong, Evelyn
Backholer, Kathryn
Harding, Jessica
Gearon, Emma
Stevenson, Christopher
Freak-Poli, Rosanne
Peeters, Anna
Journal name Systematic Reviews
Volume number 1
Issue number 1
Season Article 47
Start page 1
End page 4
Total pages 4
Publisher BioMed Central
Place of publication London, UK
Publication date 2012-10-17
ISSN 2046-4053
Keyword(s) Diabetes
Impaired glucose tolerance
Physical disability
Functional limitation
Mobiity limitation
Systematic review
Observational studies
Activities of daily living
Summary Background
Diabetes and increased age are known risk factors for physical disability. With the increasing prevalence of diabetes within our aging population, the future burden of disability is expected to increase. To date, there has not been a pooled estimate of the risk for disability associated with diabetes or its precursor states, impaired glucose tolerance and impaired fasting glucose. We aim to conduct a systematic review and meta-analysis of the association between prediabetes and diabetes with disability, and quantify the risk of association.


We will search for relevant studies in Medline via Pubmed, Embase, Cochrane library and Cumulative Index to Nursing and Allied Health Literature (CINAHL), as well as scan reference lists from relevant reviews and publications included in our review. We will review all publications that include studies on human adults (18 years and older) where information is included on diabetes status and at least one measure of disability (Activities of Daily Living (ADL), Instrumental ADL (IADL) or functional/mobility limitation), and where a risk association is available for the relationship between diabetes and/or prediabetes with disability, with reference to those without diabetes.

We will further conduct a meta-analysis to pool estimates of the risk of disability associated with prediabetes and diabetes. Sensitivity analysis will be conducted to assess for publication bias and study quality.Findings from this systematic review and meta-analysis will be widely disseminated through discussions with stake-holders, publication in a peer-reviewed journal and conference presentation.
Notes Reproduced with the kind permission of the copyright owner.
Language eng
Field of Research 111706 Epidemiology
111716 Preventive Medicine
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, BioMed Central
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060312

Document type: Journal Article
Collection: School of Health and Social Development
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