Diabetes and risk of physical disability in adults: a systematic review and meta-analysis

Wong, Evelyn, Backholer, Kathryn, Gearon, Emma, Harding, Jessica, Freak-Poli, Rosanne, Stevenson, Christopher and Peeters, Anna 2013, Diabetes and risk of physical disability in adults: a systematic review and meta-analysis, The Lancet Diabetes and Endochrinology, vol. 1, no. 2, pp. 106-114.

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Title Diabetes and risk of physical disability in adults: a systematic review and meta-analysis
Author(s) Wong, Evelyn
Backholer, Kathryn
Gearon, Emma
Harding, Jessica
Freak-Poli, Rosanne
Stevenson, Christopher
Peeters, Anna
Journal name The Lancet Diabetes and Endochrinology
Volume number 1
Issue number 2
Start page 106
End page 114
Total pages 9
Publisher Elsevier BV
Place of publication Amsterdam, Nertherlands
Publication date 2013-07-24
ISSN 2213-8587
2213-8595
Keyword(s) Diabetes
Risk of physical disability
Adults
Summary Background
According to previous reports, the risk of disability as a result of diabetes varies from none to double. Disability is an important measure of health and an estimate of the risk of disability as a result of diabetes is crucial in view of the global diabetes epidemic. We did a systematic review and meta-analysis to estimate this risk.

Methods
We searched Ovid, Medline, Embase, Cochrane Library, and Cumulative Index to Nursing and Allied Health Literature up to Aug 8, 2012. We included studies of adults that compared the risk of disability—as measured by activities of daily living (ADL), instrumental activities of daily living (IADL), or mobility—in people with and without any type of diabetes. We excluded studies of subpopulations with specific illnesses or of people in nursing homes. From the studies, we recorded population characteristics, how diabetes was diagnosed (by doctor or self-reported), domain and definition of disability, and risk estimates for disability. We calculated pooled estimates by disability type and type of risk estimate (odds ratio [OR] or risk ratio [RR]).

Results
Our systematic review returned 3224 results, from which 26 studies were included in our meta-analyses. Diabetes increased the risk of mobility disability (15 studies; OR 1·71, 95% CI 1·53—1·91; RR 1·51, 95% CI 1·38—1·64), of IADL disability (ten studies; OR 1·65, 95% CI 1·55—1·74), and of ADL disability (16 studies; OR 1·82, 95% CI 1·63—2·04; RR 1·82, 95% CI 1·40—2·36).

Interpretation
Diabetes is associated with a strong increase in the risk of physical disability. Efforts to promote healthy ageing should account for this risk through prevention and management of diabetes.

Funding
Monash University, Baker IDI Bright Sparks Foundation, Australian Postgraduate Award, VicHealth, National Health and Medical Research Council, Australian Research Council, Victorian Government.
Language eng
Field of Research 111706 Epidemiology
111716 Preventive Medicine
Socio Economic Objective 920412 Preventive Medicine
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060313

Document type: Journal Article
Collection: School of Health and Social Development
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Created: Fri, 07 Feb 2014, 16:48:44 EST by Christopher Stevenson

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