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Hyaluronan Synthesis and Myogenesis: A requirement for hyaluronan synthesis during myogenic differentiation independent of pericullular matrix formation

Hunt, Liam C, Gorman, Chris, Kintakas, Christopher, McCulloch, Daniel R, Mackie, Eleanor J and White, Jason D 2013, Hyaluronan Synthesis and Myogenesis: A requirement for hyaluronan synthesis during myogenic differentiation independent of pericullular matrix formation, Journal of Biological Chemistry, vol. 288, no. 18, pp. 13006-13021.

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Title Hyaluronan Synthesis and Myogenesis: A requirement for hyaluronan synthesis during myogenic differentiation independent of pericullular matrix formation
Author(s) Hunt, Liam C
Gorman, Chris
Kintakas, Christopher
McCulloch, Daniel R
Mackie, Eleanor J
White, Jason D
Journal name Journal of Biological Chemistry
Volume number 288
Issue number 18
Start page 13006
End page 13021
Total pages 16
Publisher American Society for Biochemistry and Molecular Biology
Place of publication Rockville, MD
Publication date 2013
ISSN 0021-9258
Keyword(s) Differentiation
Extracellular Matrix
Glycobiology
Hyaluronate
Skeletal Muscle
Hyaluronan Synthase
Myoblast
Pericellular Matrix
Summary Background
The role endogenously synthesized hyaluronan plays in myogenesis is not yet known.

Results
Hyaluronan synthase genes were expressed during skeletal muscle growth and regeneration; inhibiting these synthases prevents myoblast differentiation and fusion.

Conclusion
Endogenous hyaluronan synthesis is required for myogenic differentiation.

Significance
The necessity for hyaluronan in myogenesis has implications when considering promoting muscle growth or regeneration.
Language eng
Field of Research 060107 Enzymes
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, American Society for Biochemistry and Molecular Biology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060410

Document type: Journal Article
Collection: School of Medicine
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Created: Thu, 13 Feb 2014, 10:38:40 EST by Jane Moschetti

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