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The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass

Winbanks, Catherine E, Chen, Justin L, Qian, Hongwei, Liu, Yingying, Bernardo, Bianca C, Beyer, Claudia, Watt, Kevin I, Thomson, Rachel E, Connor, Timothy, Turner, Bradley, McMullen, Julie R, Larsson, Lars, McGee, Sean L, Harrison, Craig A and Gregorevic, Paul 2013, The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass, The Journal of Cell Biology, vol. 203, no. 2, pp. 345-357.

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Title The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass
Author(s) Winbanks, Catherine E
Chen, Justin L
Qian, Hongwei
Liu, Yingying
Bernardo, Bianca C
Beyer, Claudia
Watt, Kevin I
Thomson, Rachel E
Connor, Timothy
Turner, Bradley
McMullen, Julie R
Larsson, Lars
McGee, Sean L
Harrison, Craig A
Gregorevic, Paul
Journal name The Journal of Cell Biology
Volume number 203
Issue number 2
Start page 345
End page 357
Total pages 13
Publisher Rockefeller University Press
Place of publication New York, NY
Publication date 2013
ISSN 1540-8140
Keyword(s) Skeletal muscle mass
Bone morphogenetic protein axis
Summary Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report, for the first time, that the BMP pathway is a positive regulator of muscle mass. Increasing the expression of BMP7 or the activity of BMP receptors in muscles induced hypertrophy that was dependent on Smad1/5-mediated activation of mTOR signaling. In agreement, we observed that BMP signaling is augmented in models of muscle growth. Importantly, stimulation of BMP signaling is essential for conservation of muscle mass after disruption of the neuromuscular junction. Inhibiting the phosphorylation of Smad1/5 exacerbated denervation-induced muscle atrophy via an HDAC4-myogenin–dependent process, whereas increased BMP–Smad1/5 activity protected muscles from denervation-induced wasting. Our studies highlight a novel role for the BMP signaling pathway in promoting muscle growth and inhibiting muscle wasting, which may have significant implications for the development of therapeutics for neuromuscular disorders.
Language eng
Field of Research 111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Rockefeller University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060412

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.