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Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling

Fernandez-Rojo, Manuel A, Gongora, Milena, Fitzsimmons, Rebecca L, Martel, Nick, Martin, Sheree D, Nixon, Susan J, Brooks, Andrew J, Ikonomopoulou, Maria P, Martin, Sally, Lo, Harriet P, Myers, Stephen A, Restall, Christina, Ferguson, Charles, Pilch, Paul F, McGee, Sean L, Anderson, Robin L, Waters, Michael J, Hancock, John F, Grimmond, Sean M, Muscat, George EO and Parton, Robert G 2013, Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling, Cell Reports, vol. 4, no. 2, pp. 238-247.

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Title Caveolin-1 Is Necessary for Hepatic Oxidative Lipid Metabolism: Evidence for Crosstalk between Caveolin-1 and Bile Acid Signaling
Author(s) Fernandez-Rojo, Manuel A
Gongora, Milena
Fitzsimmons, Rebecca L
Martel, Nick
Martin, Sheree D
Nixon, Susan J
Brooks, Andrew J
Ikonomopoulou, Maria P
Martin, Sally
Lo, Harriet P
Myers, Stephen A
Restall, Christina
Ferguson, Charles
Pilch, Paul F
McGee, Sean L
Anderson, Robin L
Waters, Michael J
Hancock, John F
Grimmond, Sean M
Muscat, George EO
Parton, Robert G
Journal name Cell Reports
Volume number 4
Issue number 2
Start page 238
End page 247
Total pages 10
Publisher Cell Press
Place of publication Cambridge, MA
Publication date 2013
ISSN 2211-1247
Keyword(s) Caveolin-1
Hepatic Oxidative Lipid Metabolism
Bile Acid Signaling
Summary Caveolae and caveolin-1 (CAV1) have been linked to several cellular functions. However, a model explaining their roles in mammalian tissues in vivo is lacking. Unbiased expression profiling in several tissues and cell types identified lipid metabolism as the main target affected by CAV1 deficiency. CAV1−/− mice exhibited impaired hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent oxidative fatty acid metabolism and ketogenesis. Similar results were recapitulated in CAV1-deficient AML12 hepatocytes, suggesting at least a partial cell-autonomous role of hepatocyte CAV1 in metabolic adaptation to fasting. Finally, our experiments suggest that the hepatic phenotypes observed in CAV1−/− mice involve impaired PPARα ligand signaling and attenuated bile acid and FXRα signaling. These results demonstrate the significance of CAV1 in (1) hepatic lipid homeostasis and (2) nuclear hormone receptor (PPARα, FXRα, and SHP) and bile acid signaling.
Language eng
Field of Research 111699 Medical Physiology not elsewhere classified
Socio Economic Objective 920105 Digestive System Disorders
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2013, Cell Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30060480

Document type: Journal Article
Collections: School of Medicine
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