Openly accessible

Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007

Cooke, Benjamin, Smith, Andrew, Diggle, Mathew, Lamb, Karen, Robertson, Christopher, Inverarity, Donald, Jefferies, Johanna, Edwards, Giles, Mitchell, Timothy, Clarke, Stuart and McMenamin, Jim 2010, Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007, Journal of Medical Microbiology, vol. 59, no. 10, pp. 1212-1218, doi: 10.1099/jmm.0.022954-0.

Attached Files
Name Description MIMEType Size Downloads

Title Antibiotic resistance in invasive Streptococcus pneumoniae isolates identified in Scotland between 1999 and 2007
Author(s) Cooke, Benjamin
Smith, Andrew
Diggle, Mathew
Lamb, KarenORCID iD for Lamb, Karen orcid.org/0000-0001-9782-8450
Robertson, Christopher
Inverarity, Donald
Jefferies, Johanna
Edwards, Giles
Mitchell, Timothy
Clarke, Stuart
McMenamin, Jim
Journal name Journal of Medical Microbiology
Volume number 59
Issue number 10
Start page 1212
End page 1218
Total pages 7
Publisher Society for General Microbiology
Place of publication London, UK
Publication date 2010
ISSN 0022-2615
1473-5644
Keyword(s) Antibiotic resistance
Streptococcus pneumoniae
Scotland
Summary Data from 4727 invasive isolates of Streptococcus pneumoniae submitted to the Scottish Haemophilus, Legionella, Meningococcus and Pneumococcus Reference Laboratory between 1999 and 2007 were analysed to establish susceptibility profiles to penicillin, erythromycin and cefotaxime. Pneumococcal resistance to penicillin over the study period remained low, with only 0.2 % (n=7/4727) of isolates falling into this category (MIC ≥2 mg l−1). These isolates have been sporadic, and have mainly represented serogroup 14 (ST9) and 9 (ST156). In comparison, the ‘intermediate sensitivity’ group (MIC 0.12–1 mg l−1) ranged between 2 and 6 % per year, the majority from serogroup 9 (ST156). Over the study period, we found that 12 % (n=585/4727) of isolates were erythromycin-resistant (MIC >0.5 mg l−1), with the majority (n=467; 80 %) of these isolates identified as serogroup 14 (ST9). Cephalosporin resistance (cefotaxime MIC >1 mg l−1) was found in only 0.06 % (n=2/3135) of isolates. Internationally recognized clones (Pneumococcal Molecular Epidemiology Network) accounted for 35 % (n=28/81) of the penicillin non-susceptible isolates and 75 % (n=248/330) of the macrolide-resistant isolates, with ST9 and ST306 predominating. Between 1999 and 2007 we found that 11.6 % (n=18/155) of the penicillin non-susceptible isolates and 4.8 % (n=28/585) of the macrolide-resistant isolates were from serogroups not covered by the 7-valent conjugate pneumococcal vaccine in use in the UK since 2006. Susceptibility to first-line antimicrobial agents for invasive pneumococcal disease in Scotland remained high over the period 1999–2007.
Language eng
DOI 10.1099/jmm.0.022954-0
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061315

Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in TR Web of Science
Scopus Citation Count Cited 7 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 269 Abstract Views, 3 File Downloads  -  Detailed Statistics
Created: Thu, 06 Mar 2014, 11:27:44 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.