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Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)

Fanson, Benjamin G, Weldon, Christopher W, Perez-Staples, Diana, Simpson, Stephen J and Taylor, Phillip W 2009, Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni), Aging Cell, vol. 8, no. 5, pp. 514-523, doi: 10.1111/j.1474-9726.2009.00497.x.

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Title Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)
Author(s) Fanson, Benjamin G
Weldon, Christopher W
Perez-Staples, Diana
Simpson, Stephen J
Taylor, Phillip W
Journal name Aging Cell
Volume number 8
Issue number 5
Start page 514
End page 523
Total pages 10
Publisher Blackwell Publishing
Place of publication London, UK
Publication date 2009
ISSN 1474-9718
Keyword(s) Caloric restriction
Geometric framework
Summary Caloric restriction (CR) has been widely accepted as a mechanism explaining increased lifespan (LS) in organisms subjected to dietary restriction (DR), but recent studies investigating the role of nutrients have challenged the role of CR in extending longevity. Fuelling this debate is the difficulty in experimentally disentangling CR and nutrient effects due to compensatory feeding (CF) behaviour. We quantified CF by measuring the volume of solution imbibed and determined how calories and nutrients influenced LS and fecundity in unmated females of the Queensland fruit fly, Bactocera tryoni (Diptera: Tephritidae). We restricted flies to one of 28 diets varying in carbohydrate:protein (C:P) ratios and concentrations. On imbalanced diets, flies overcame dietary dilutions, consuming similar caloric intakes for most dilutions. The response surface for LS revealed that increasing C:P ratio while keeping calories constant extended LS, with the maximum LS along C:P ratio of 21:1. In general, LS was reduced as caloric intake decreased. Lifetime egg production was maximized at a C:P ratio of 3:1. When given a choice of separate sucrose and yeast solutions, each at one of five concentrations (yielding 25 choice treatments), flies regulated their nutrient intake to match C:P ratio of 3:1. Our results (i) demonstrate that CF can overcome dietary dilutions; (ii) reveal difficulties with methods presenting fixed amounts of liquid diet; (iii) illustrate the need to measure intake to account for CF in DR studies and (iv) highlight nutrients rather than CR as a dominant influence on LS.
Language eng
DOI 10.1111/j.1474-9726.2009.00497.x
Field of Research 059999 Environmental Sciences not elsewhere classified
Socio Economic Objective 970105 Expanding Knowledge in the Environmental Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, Blackwell Publishing
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Document type: Journal Article
Collection: Centre for Integrative Ecology
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