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A novel model of sensitization and oral tolerance to peanut protein

Strid, Jessica, Thomson, Melanie, Hourihane, Jonathan, Kimber, Ian and Strobel, Stephan 2004, A novel model of sensitization and oral tolerance to peanut protein, Immunology, vol. 113, no. 3, pp. 293-303, doi: 10.1111/j.1365-2567.2004.01989.x.

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Title A novel model of sensitization and oral tolerance to peanut protein
Author(s) Strid, Jessica
Thomson, Melanie
Hourihane, Jonathan
Kimber, Ian
Strobel, Stephan
Journal name Immunology
Volume number 113
Issue number 3
Start page 293
End page 303
Total pages 11
Publisher Blackwell Publishing
Place of publication London, UK
Publication date 2004
ISSN 0019-2805
1365-2567
Keyword(s) Sensitization
Oral tolerance
Peanut
Allergy
Summary The prevalence of food allergic diseases is rising and poses an increasing clinical problem. Peanut allergy affects around 1% of the population and is a common food allergy associated with severe clinical manifestations. The exact route of primary sensitization is unknown although the gastrointestinal immune system is likely to play an important role. Exposure of the gastrointestinal tract to soluble antigens normally leads to a state of antigen-specific systemic hyporesponsiveness (oral tolerance). A deviation from this process is thought to be responsible for food-allergic diseases. In this study, we have developed a murine model to investigate immunoregulatory processes after ingestion of peanut protein and compared this to a model of oral tolerance to chicken egg ovalbumin (OVA). We demonstrate that oral tolerance induction is highly dose dependent and differs for the allergenic proteins peanut and OVA. Tolerance to peanut requires a significantly higher oral dose than tolerance to OVA. Low doses of peanut are more likely to induce oral sensitization and increased production of interleukin-4 and specific immunoglobulin E upon challenge. When tolerance is induced both T helper 1 and 2 responses are suppressed. These results show that oral tolerance to peanut can be induced experimentally but that peanut proteins have a potent sensitizing effect. This model can now be used to define regulatory mechanisms following oral exposure to allergenic proteins on local, mucosal and systemic immunity and to investigate the immunomodulating effects of non-oral routes of allergen exposure on the development of allergic sensitization to peanut and other food allergens.
Language eng
DOI 10.1111/j.1365-2567.2004.01989.x
Field of Research 110701 Allergy
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061395

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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