Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency

Harris, Paul R, Serrano, Carolina A, Villagran, Andrea, Walker, Marjorie M, Thomson, Melanie, Duarte, Ignacio, Windle, Henry J and Crabtree, Jean E 2013, Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency, Journal of Clinical Pathology, vol. 66, no. 4, pp. 343-347, doi: 10.1136/jclinpath-2012-201243.

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Title Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency
Author(s) Harris, Paul R
Serrano, Carolina A
Villagran, Andrea
Walker, Marjorie M
Thomson, Melanie
Duarte, Ignacio
Windle, Henry J
Crabtree, Jean E
Journal name Journal of Clinical Pathology
Volume number 66
Issue number 4
Start page 343
End page 347
Total pages 5
Publisher BMJ Publishing Group
Place of publication London, England
Publication date 2013
ISSN 0021-9746
Keyword(s) Iron deficiency
Summary Aims Acute Helicobacter pylori infection is associated with transient hypochlorhydria. In H pylori-associated atrophy, hypochlorhydria has a role in iron deficiency (ID) through changes in the physiology of iron-complex absorption. The aims were to evaluate the association between H pylori-associated hypochlorhydria and ID in children. Methods Symptomatic children (n=123) were prospectively enrolled. Blood, gastric juice and gastric biopsies were taken, respectively, for haematological analyses, pH assessment and H pylori determination, and duodenal biopsies for exclusion of coeliac disease. Stool samples were collected for parasitology/microbiology. Thirteen children were excluded following parasitology and duodenal histopathology, and five due to impaired blood analysis. Results Ten children were hypochlorhydric (pH>4) and 33 were H pylori positive. In H pylori-positive children with pH>4 (n=6) serum iron and transferrin saturation levels % were significantly lower (p<0.01) than H pylori-positive children with pH≤4. No differences in ferritin, or total iron binding capacity, were observed. In H pylori-negative children with pH>4, iron and transferrin saturation were not significantly different from children with pH≤4. Conclusions Low serum iron and transferrin in childhood H pylori infection is associated with hypochlorhydria. In uninfected children, hypochlorhydria was not associated with altered serum iron parameters, indicating a combination of H pylori infection and/or inflammation, and hypochlorhydria has a role in the aetiology of ID. Although H pylori-associated hypochlorhydria is transient during acute gastritis, this alters iron homeostasis with clinical impact in developing countries with a high H pylori prevalence.
Language eng
DOI 10.1136/jclinpath-2012-201243
Field of Research 110309 Infectious Diseases
110303 Clinical Microbiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, BMJ Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061406

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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