You are not logged in.

Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency

Harris, Paul R, Serrano, Carolina A, Villagran, Andrea, Walker, Marjorie M, Thomson, Melanie, Duarte, Ignacio, Windle, Henry J and Crabtree, Jean E 2013, Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency, Journal of Clinical Pathology, vol. 66, no. 4, pp. 343-347, doi: 10.1136/jclinpath-2012-201243.

Attached Files
Name Description MIMEType Size Downloads

Title Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency
Author(s) Harris, Paul R
Serrano, Carolina A
Villagran, Andrea
Walker, Marjorie M
Thomson, Melanie
Duarte, Ignacio
Windle, Henry J
Crabtree, Jean E
Journal name Journal of Clinical Pathology
Volume number 66
Issue number 4
Start page 343
End page 347
Total pages 5
Publisher BMJ Publishing Group
Place of publication London, England
Publication date 2013
ISSN 0021-9746
Keyword(s) Iron deficiency
Children
Helicobacter
Pylori-associated
Hypochlorhydria
Summary Aims Acute Helicobacter pylori infection is associated with transient hypochlorhydria. In H pylori-associated atrophy, hypochlorhydria has a role in iron deficiency (ID) through changes in the physiology of iron-complex absorption. The aims were to evaluate the association between H pylori-associated hypochlorhydria and ID in children. Methods Symptomatic children (n=123) were prospectively enrolled. Blood, gastric juice and gastric biopsies were taken, respectively, for haematological analyses, pH assessment and H pylori determination, and duodenal biopsies for exclusion of coeliac disease. Stool samples were collected for parasitology/microbiology. Thirteen children were excluded following parasitology and duodenal histopathology, and five due to impaired blood analysis. Results Ten children were hypochlorhydric (pH>4) and 33 were H pylori positive. In H pylori-positive children with pH>4 (n=6) serum iron and transferrin saturation levels % were significantly lower (p<0.01) than H pylori-positive children with pH≤4. No differences in ferritin, or total iron binding capacity, were observed. In H pylori-negative children with pH>4, iron and transferrin saturation were not significantly different from children with pH≤4. Conclusions Low serum iron and transferrin in childhood H pylori infection is associated with hypochlorhydria. In uninfected children, hypochlorhydria was not associated with altered serum iron parameters, indicating a combination of H pylori infection and/or inflammation, and hypochlorhydria has a role in the aetiology of ID. Although H pylori-associated hypochlorhydria is transient during acute gastritis, this alters iron homeostasis with clinical impact in developing countries with a high H pylori prevalence.
Language eng
DOI 10.1136/jclinpath-2012-201243
Field of Research 110309 Infectious Diseases
110303 Clinical Microbiology
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, BMJ Publishing Group
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061406

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 14 times in TR Web of Science
Scopus Citation Count Cited 18 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 149 Abstract Views, 1 File Downloads  -  Detailed Statistics
Created: Thu, 06 Mar 2014, 11:55:29 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.