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Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types

Inverarity, Donald, Lamb, Karen, Diggle, Mathew, Robertson, Chris, Greenhalgh, David, Mitchell, Tim J, Smith, Andrew, Jefferies, Johanna M C, Clarke, Stuart C, McMenamin, Jim and Edwards, Giles F S 2011, Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types, Journal of Medical Microbiology, vol. 60, no. 6, pp. 793-802, doi: 10.1099/jmm.0.028803-0.

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Title Death or survival from invasive pneumococcal disease in Scotland: associations with serogroups and multilocus sequence types
Author(s) Inverarity, Donald
Lamb, KarenORCID iD for Lamb, Karen orcid.org/0000-0001-9782-8450
Diggle, Mathew
Robertson, Chris
Greenhalgh, David
Mitchell, Tim J
Smith, Andrew
Jefferies, Johanna M C
Clarke, Stuart C
McMenamin, Jim
Edwards, Giles F S
Journal name Journal of Medical Microbiology
Volume number 60
Issue number 6
Start page 793
End page 802
Total pages 10
Publisher Society for General Microbiology
Place of publication London, UK
Publication date 2011
ISSN 0022-2615
1473-5644
Keyword(s) Pneumococcal disease
Scotland
Serogroups
Multilocus
Summary We describe associations between death from invasive pneumococcal disease (IPD) and particular serogroups and sequence types (STs) determined by multilocus sequence typing (MLST) using data from Scotland. All IPD episodes where blood or cerebrospinal fluid (CSF) culture isolates were referred to the Scottish Haemophilus, Legionella, Meningococcal and Pneumococcal Reference Laboratory (SHLMPRL) from January 1992 to February 2007 were matched to death certification records by the General Register Office for Scotland. This represented 5959 patients. The median number of IPD cases in Scotland each year was 292. Deaths, from any cause, within 30 days of pneumococcal culture from blood or CSF were considered to have IPD as a contributing factor. Eight hundred and thirty-three patients died within 30 days of culture of Streptococcus pneumoniae from blood or CSF [13.95 %; 95 % confidence interval (13.10, 14.80)]. The highest death rates were in patients over the age of 75. Serotyping data exist for all years but MLST data were only available from 2001 onward. The risk ratio of dying from infection due to particular serogroups or STs compared to dying from IPD due to all other serogroups or STs was calculated. Fisher’s exact test with Bonferroni adjustment for multiple testing was used. Age adjustment was accomplished using the Cochran–Mantel–Haenszel test and 95 % confidence intervals were reported. Serogroups 3, 11 and 16 have increased probability of causing fatal IPD in Scotland while serogroup 1 IPD has a reduced probability of causing death. None of the 20 most common STs were significantly associated with death within 30 days of pneumococcal culture, after age adjustment. We conclude that there is a stronger association between a fatal outcome and pneumococcal capsular serogroup than there is between a fatal outcome and ST.
Language eng
DOI 10.1099/jmm.0.028803-0
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Society for General Microbiology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061420

Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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