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Rheumatoid arthritis and incident fracture in women: a case-control study

Brennan, Sharon L., Toomey, Liesje, Kotowicz, Mark A., Henry, Margaret J., Griffiths, Hedley and Pasco, Julie A. 2014, Rheumatoid arthritis and incident fracture in women: a case-control study, BMC musculoskeletal disorders, vol. 15, no. 13, doi: 10.1186/1471-2474-15-13.

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Title Rheumatoid arthritis and incident fracture in women: a case-control study
Author(s) Brennan, Sharon L.
Toomey, Liesje
Kotowicz, Mark A.ORCID iD for Kotowicz, Mark A. orcid.org/0000-0002-8094-1411
Henry, Margaret J.
Griffiths, Hedley
Pasco, Julie A.ORCID iD for Pasco, Julie A. orcid.org/0000-0002-8968-4714
Journal name BMC musculoskeletal disorders
Volume number 15
Issue number 13
Total pages 6
Publisher BioMed Central Ltd
Place of publication London, England
Publication date 2014
ISSN 1471-2474
Keyword(s) incident fracture
rheumatoid arthritis
epidemiology
women
Summary Background:
To examine fracture incidence in women with rheumatoid arthritis (RA) for an entire geographical region of south-eastern Australia.

Methods:
Women aged 35 years and older, resident in the Barwon Statistical Division (BSD) and clinically diagnosed with RA 1994–2001 were eligible for inclusion as cases (n =1,008). The control population (n = 172,422) comprised the entire female BSD population aged 35 years and older, excluding those individuals identified as cases. Incident fractures were extracted from the prospective Geelong Osteoporosis Study Fracture Grid. We calculated rate ratios (RR) and 95% confidence intervals (CI) to compare the age- adjusted rate of fracture between the RA and non-RA populations, and used a chi-square test to compare proportions of fractures between women with and without RA, and a two-sided Mann–Whitney U-test to examine age-differences.

Results:
Among 1,008 women with RA, 19 (1.9%) sustained a fracture, compared to 1,981 fractures sustained by the 172,422 women without RA (1.2%). Fracture rates showed a trend for being greater among women diagnosed with RA (age-adjusted RR 1.43, 95%CI 0.98-2.09, p= 0.08). Women with RA sustained vertebral fractures at twice the expected frequency, whereas hip fractures were underrepresented in the RA population (p< 0.001). RA status was not associated with the likelihood of sustaining a fracture at sites adjacent to joints most commonly affected by RA (p= 0.22).

Conclusion:
Given that women with RA have a greater risk of fracture compared to women without RA, these patients may be a suitable target population for anti-resorptive agents; however, larger studies are warranted.
Language eng
DOI 10.1186/1471-2474-15-13
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Grant ID NHMRC 628582
Copyright notice ©2014, BioMed Central
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061470

Document type: Journal Article
Collections: School of Medicine
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Created: Mon, 10 Mar 2014, 11:24:25 EST by Penny Andrews

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.