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Younger siblings, C-Reactive protein, and risk of age-related macular degeneration

Cohn, Amy C, Busija, Lucy, Robman, Liubov D, Dimitrov, Peter N, Varsamidis, Mary, Lim, Lyndell L, Baird, Paul N and Guymer, Robyn H 2013, Younger siblings, C-Reactive protein, and risk of age-related macular degeneration, American Journal of Epidemiology, vol. 177, no. 9, pp. 933-943, doi: 10.1093/aje/kws332.

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Title Younger siblings, C-Reactive protein, and risk of age-related macular degeneration
Author(s) Cohn, Amy C
Busija, Lucy
Robman, Liubov D
Dimitrov, Peter N
Varsamidis, Mary
Lim, Lyndell L
Baird, Paul N
Guymer, Robyn H
Journal name American Journal of Epidemiology
Volume number 177
Issue number 9
Start page 933
End page 943
Total pages 11
Publisher Oxford University Press
Place of publication Oxford, UK
Publication date 2013
ISSN 0002-9262
1476-6256
Keyword(s) Age-related macular degeneration
C-reactive protein
Inflammation
Sibling exposure
Summary In this study, we examined the relationship between exposure to siblings and 1) the risk of age-related macular degeneration (AMD) and 2) C-reactive protein levels. We retrospectively analyzed pooled cross-sectional data from 2 studies: the Cardiovascular Health and Age-Related Maculopathy Study (2001–2002) and the Age-Related Maculopathy Statin Study (2004–2006). Associations between number of siblings and AMD were assessed by using multinomial logistic regression. Associations between number of siblings and C-reactive protein levels were examined by using a generalized linear model for γ distribution. A higher number of younger siblings was associated with significantly lower odds of early AMD in those with a family history of AMD (odds ratio = 0.2, 95% confidence interval: 0.1, 0.8) (P = 0.022) but was unrelated to AMD for those who had no family history of the disease (odds ratio = 1.0, 95% confidence interval: 0.9, 1.2) (P = 0.874). A higher number of younger siblings correlated with lower C-reactive protein levels (β = −0.19, 95% confidence interval: −0.38, −0.01) (P = 0.036). This supports the theory that immune modulation contributes to AMD pathogenesis and suggests that exposure to younger siblings might be protective when there is a family history of AMD.
Language eng
DOI 10.1093/aje/kws332
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Oxford University Press
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061482

Document type: Journal Article
Collection: PVC's Office - Health
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Created: Mon, 10 Mar 2014, 13:31:51 EST by Lucy Busija

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