The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study

Aung, Khin Z, Makeyeva, Galina, Adams, Madeleine K, Chong, Elaine W-T, Busija, Lucy, Giles, Graham G, English, Dallas R, Hopper, John, Baird, Paul N, Guymer, Robyn H and Robman, Liubov D 2013, The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study, Retina, vol. 33, no. 5, pp. 1026-1034, doi: 10.1097/IAE.0b013e3182733f25.

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Title The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study
Author(s) Aung, Khin Z
Makeyeva, Galina
Adams, Madeleine K
Chong, Elaine W-T
Busija, Lucy
Giles, Graham G
English, Dallas R
Hopper, John
Baird, Paul N
Guymer, Robyn H
Robman, Liubov D
Journal name Retina
Volume number 33
Issue number 5
Start page 1026
End page 1034
Total pages 9
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, PA
Publication date 2013
ISSN 0275-004X
Keyword(s) Epiretinal membranes
Summary Purpose
To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this population.

The Melbourne Collaborative Cohort Study is a prospective study investigating the role of diet and life style in the causation of common chronic diseases. Eighty-six percent of participants were of Northern European origin born in Australia or United Kingdom and 14% were migrants from Greece or Italy (Southern European origin). Nonmydriatic digital retinal photography was implemented at Melbourne Collaborative Cohort Study follow-up. The ERMs were recorded as cellophane macular reflex without retinal folds or preretinal macular fibrosis (PMF) with retinal folds.

A total of 22,406 participants had retinal photography, 95% (n = 21,241) were eligible for ERM grading. The ERM prevalence were 8.9% (1,882); cellophane macular reflex, 4.9% (1,047); and preretinal macular fibrosis, 3.9% (835). After adjustment for age, sex, level of education, smoking status, level of cholesterol, body mass index, waist-to-hip ratio, waist measurement, blood pressure, diabetes, and stroke, increasing age and Southern European ethnicity was significantly associated with ERMs. Overall, in Southern Europeans, ERMs odd ratio was 1.97 (95% confidence intervals, 1.67–2.31), P < 0.001; preretinal macular fibrosis was 1.82 (95% confidence intervals, 1.43–2.31), P < 0.001; and cellophane macular reflex was 1.93 (1.57–2.38), P < 0.001.


In an older Australian population, the prevalence of ERMs was 8.9% and was almost two times higher in participants of Southern European origin than Northern European origin.
Language eng
DOI 10.1097/IAE.0b013e3182733f25
Field of Research 111301 Ophthalmology
Socio Economic Objective 920107 Hearing, Vision, Speech and Their Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Lippincott Williams & Wilkins
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Document type: Journal Article
Collections: Faculty of Health
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Created: Mon, 10 Mar 2014, 14:30:15 EST by Lucy Busija

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