The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study

Aung, Khin Z, Makeyeva, Galina, Adams, Madeleine K, Chong, Elaine W-T, Busija, Lucy, Giles, Graham G, English, Dallas R, Hopper, John, Baird, Paul N, Guymer, Robyn H and Robman, Liubov D 2013, The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study, Retina, vol. 33, no. 5, pp. 1026-1034.

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Title The prevalence and risk factors of epiretinal membranes: the Melbourne collaborative cohort study
Author(s) Aung, Khin Z
Makeyeva, Galina
Adams, Madeleine K
Chong, Elaine W-T
Busija, Lucy
Giles, Graham G
English, Dallas R
Hopper, John
Baird, Paul N
Guymer, Robyn H
Robman, Liubov D
Journal name Retina
Volume number 33
Issue number 5
Start page 1026
End page 1034
Total pages 9
Publisher Lippincott Williams & Wilkins
Place of publication Philadelphia, PA
Publication date 2013
ISSN 0275-004X
Keyword(s) Epiretinal membranes
Melbourne
Summary Purpose
To determine the prevalence of epiretinal membranes (ERMs) in Melbourne, Australia and its risk factors in this population.

Methods
The Melbourne Collaborative Cohort Study is a prospective study investigating the role of diet and life style in the causation of common chronic diseases. Eighty-six percent of participants were of Northern European origin born in Australia or United Kingdom and 14% were migrants from Greece or Italy (Southern European origin). Nonmydriatic digital retinal photography was implemented at Melbourne Collaborative Cohort Study follow-up. The ERMs were recorded as cellophane macular reflex without retinal folds or preretinal macular fibrosis (PMF) with retinal folds.

Results
A total of 22,406 participants had retinal photography, 95% (n = 21,241) were eligible for ERM grading. The ERM prevalence were 8.9% (1,882); cellophane macular reflex, 4.9% (1,047); and preretinal macular fibrosis, 3.9% (835). After adjustment for age, sex, level of education, smoking status, level of cholesterol, body mass index, waist-to-hip ratio, waist measurement, blood pressure, diabetes, and stroke, increasing age and Southern European ethnicity was significantly associated with ERMs. Overall, in Southern Europeans, ERMs odd ratio was 1.97 (95% confidence intervals, 1.67–2.31), P < 0.001; preretinal macular fibrosis was 1.82 (95% confidence intervals, 1.43–2.31), P < 0.001; and cellophane macular reflex was 1.93 (1.57–2.38), P < 0.001.

Conclusion

In an older Australian population, the prevalence of ERMs was 8.9% and was almost two times higher in participants of Southern European origin than Northern European origin.
Language eng
Field of Research 111301 Ophthalmology
Socio Economic Objective 920107 Hearing, Vision, Speech and Their Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, Lippincott Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061492

Document type: Journal Article
Collection: PVC's Office - Health
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Created: Mon, 10 Mar 2014, 14:30:15 EST by Lucy Busija

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