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Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD

Wickremasinghe, Sanjeewa S., Busija, Lucy, Guymer, Robyn H., Wong, Tien Y. and Qureshi, Salmaan 2012, Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD, Investigative ophthalmology & visual science, vol. 53, no. 1, pp. 37-41, doi: 10.1167/iovs.11-7689.

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Title Retinal venular caliber predicts visual outcome after intravitreal ranibizumab injection treatments for neovascular AMD
Author(s) Wickremasinghe, Sanjeewa S.
Busija, Lucy
Guymer, Robyn H.
Wong, Tien Y.
Qureshi, Salmaan
Journal name Investigative ophthalmology & visual science
Volume number 53
Issue number 1
Start page 37
End page 41
Total pages 5
Publisher Association for Research in Vision and Ophthalmology
Place of publication [St Louis, Mo.]
Publication date 2012-01
ISSN 0146-0404
1552-5783
Keyword(s) eyes
neovascular AMD
intravitreal ranibizumab
neovascularization
age-related vascular degeneration
Summary Purpose
To examine whether baseline retinal vascular caliber predicts visual response to intravitreal ranibizumab injections in patients with neovascular age-related macular degeneration (AMD).

Methods
In this prospective cohort study, patients with neovascular AMD received three monthly intravitreal injections of ranibizumab, followed by as needed dosing up to 1 year. Retinal vascular caliber was measured from digital fundus photographs at baseline and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE), representing average caliber of arterioles and venules, respectively. Visual outcome at 12 months was assessed and the relation to baseline retinal vascular caliber was determined.

Results
A total of 88 eyes were analyzed at baseline. After accounting for age, sex, size of choroidal neovascularization, and number of injections, patients who deteriorated in visual acuity at 12 months had significantly larger baseline CRVE, 243.10 μm (95% confidence interval [CI], 227.01–259.19), compared with those who were stable, 214.30 μm (95% CI, 205.79–222.81) and those who improved, 215.26 μm (95% CI, 204.69–225.84; P = 0.007). Baseline CRAE did not differ significantly from eyes whose vision deteriorated, 150.12 μm (95% CI, 140.67–159.57), compared with those remaining stable, 143.64 μm (95% CI, 138.64–148.63), or gaining vision 142.92 μm (95% CI, 136.71–149.13; P = 0.69).

Conclusions
In eyes with neovascular AMD treated with intravitreal ranibizumab, larger baseline retinal venular caliber was significantly associated with a poorer response to treatment, possibly reflecting increased disease severity.
Language eng
DOI 10.1167/iovs.11-7689
Field of Research 111301 - Ophthalmology
Socio Economic Objective 920107 - Hearing, Vision, Speech and Their Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, Association for Research in Vision and Ophthalmology
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061497

Document type: Journal Article
Collection: PVC's Office - Health
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Created: Mon, 10 Mar 2014, 14:52:49 EST by Lucy Busija

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