A surface-stress-based microcantilever aptasensor

Lim, Yang Choon, Kouzani, Abbas Z., Duan, Wei, Dai, Xiujuan J., Kaynak, Akif and Mair, Douglas 2014, A surface-stress-based microcantilever aptasensor, IEEE transactions on biomedical circuits and systems, vol. 8, no. 1, pp. 15-24, doi: 10.1109/TBCAS.2013.2286255.

Attached Files
Name Description MIMEType Size Downloads

Title A surface-stress-based microcantilever aptasensor
Author(s) Lim, Yang Choon
Kouzani, Abbas Z.ORCID iD for Kouzani, Abbas Z. orcid.org/0000-0002-6292-1214
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Dai, Xiujuan J.
Kaynak, AkifORCID iD for Kaynak, Akif orcid.org/0000-0002-6679-657X
Mair, Douglas
Journal name IEEE transactions on biomedical circuits and systems
Volume number 8
Issue number 1
Start page 15
End page 24
Total pages 10
Publisher IEEE
Place of publication Piscataway, NJ
Publication date 2014
ISSN 1932-4545
Keyword(s) Aptasensor
Summary Biosensors based on microcantilevers convert biological recognition events into measurable mechanical displacements. They offer advantages such as small size, low sample volume, label-free detection, ease of integration, high-throughput analysis, and low development cost. The design and development of a microcantilever-based aptasensor employing SU-8 polymer as the fabrication material is presented in this paper. Aptamers are employed as bioreceptor elements because they exhibit superior specificity compared to antibodies due to their small size and physicochemical stability. To immobilise thrombin DNA aptamer on the bare SU-8 surface of the aptasensor, a combined plasma mode treatment method is implemented which modifies the surface of the aptasensor. Label-free detection of thrombin molecules using the fabricated aptasensor is successfully demonstrated. The measured deflection is one order of magnitude higher than that of a silicon nitride microcantilever biosensor. The developed aptasensor also demonstrates high specificity.
Language eng
DOI 10.1109/TBCAS.2013.2286255
Field of Research 091306 Microelectromechanical Systems (MEMS)
Socio Economic Objective 861502 Medical Instruments
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, IEEE
Persistent URL http://hdl.handle.net/10536/DRO/DU:30061683

Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in TR Web of Science
Scopus Citation Count Cited 7 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 609 Abstract Views, 10 File Downloads  -  Detailed Statistics
Created: Tue, 18 Mar 2014, 08:40:37 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.