Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications

Anderson, George, Berk, Michael, Dean, Olivia, Moylan, Steven and Maes, Michael 2014, Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications, CNS Drugs, vol. 28.

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Title Role of immune-inflammatory and oxidative and nitrosative stress pathways in the etiology of depression: therapeutic implications
Author(s) Anderson, George
Berk, Michael
Dean, Olivia
Moylan, Steven
Maes, Michael
Journal name CNS Drugs
Volume number 28
Total pages 10
Publisher Adis International
Place of publication Aukland, New Zealand
Publication date 2014
ISSN 1172-7047
Keyword(s) depression
immuneinflammatory processes
biological changes
antidepressants
Summary Accumulating data have led to a re-conceptualization of depression that emphasizes the role of immuneinflammatory processes, coupled to oxidative and nitrosative stress (O&NS). These in turn drive the production of neuroregulatory tryptophan catabolites (TRYCATs), driving tryptophan away from serotonin, melatonin, and Nacetylserotonin production, and contributing to central dysregulation. This revised perspective better encompasses the diverse range of biological changes occurring in depression and in doing so provides novel and readily attainable treatment targets, as well as potential screening investigations prior to treatment initiation. We briefly review the role that immune-inflammatory, O&NS, and TRYCAT pathways play in the etiology, course, and treatment of depression. We then discuss the pharmacological treatment implications arising from this, including the potentiation of currently available antidepressants by the adjunctive use of immune- and O&NS- targeted therapies. The use of such a frame of reference and the treatment benefits attained are likely to have wider implications and utility for depression-associated conditions, including the neuroinflammatory and (neuro)degenerative disorders.
Language eng
Field of Research 110319 Psychiatry (incl Psychotherapy)
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2014, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30062452

Document type: Journal Article
Collection: School of Medicine
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