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Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression

Culverhouse, Robert C., Bowes, Lucy, Breslau, Naomi, Nurnberger Jr, John I., Burmeister, Margit, Fergusson, David M., Munafo, Marcus, Saccone, Nancy L., Bierut, Laura J. and Olsson, Craig - On behalf of the 5-HTTLPR, Stress and Depression Consortium 2013, Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression, BMC psychiatry, vol. 13, no. 304, pp. 1-11, doi: 10.1186/1471-244X-13-304.

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Title Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
Author(s) Culverhouse, Robert C.
Bowes, Lucy
Breslau, Naomi
Nurnberger Jr, John I.
Burmeister, Margit
Fergusson, David M.
Munafo, Marcus
Saccone, Nancy L.
Bierut, Laura J.
Olsson, Craig - On behalf of the 5-HTTLPR, Stress and Depression ConsortiumORCID iD for Olsson, Craig - On behalf of the 5-HTTLPR, Stress and Depression Consortium orcid.org/0000-0002-5927-2014
Journal name BMC psychiatry
Volume number 13
Issue number 304
Start page 1
End page 11
Total pages 11
Publisher BioMed Central Ltd
Place of publication London, England
Publication date 2013
ISSN 1471-244X
Summary Background: Debate is ongoing about what role, if any, variation in the serotonin transporter linked polymorphic region (5-HTTLPR) plays in depression. Some studies report an interaction between 5-HTTLPR variation and stressful life events affecting the risk for depression, others report a main effect of 5-HTTLPR variation on depression, while others find no evidence for either a main or interaction effect. Meta-analyses of multiple studies have also reached differing conclusions.

Methods/Design:
To improve understanding of the combined roles of 5-HTTLPR variation and stress in the development of depression, we are conducting a meta-analysis of multiple independent datasets. This coordinated approach utilizes new analyses performed with centrally-developed, standardized scripts. This publication documents the protocol for this collaborative, consortium-based meta-analysis of 5-HTTLPR variation, stress, and depression.

Study eligibility criteria: Our goal is to invite all datasets, published or unpublished, with 5-HTTLPR genotype and assessments of stress and depression for at least 300 subjects. This inclusive approach is to minimize potential impact from publication bias.

Data sources: This project currently includes investigators from 35 independent groups, providing data on at least N = 33,761 participants.  The analytic plan was determined prior to starting data analysis. Analyses of individual study datasets will be performed by the investigators who collected the data using centrally-developed standardized analysis scripts to ensure a consistent analytical approach across sites. The consortium as a group will review and interpret the meta-analysis results.

Discussion:
Variation in 5-HTTLPR is hypothesized to moderate the response to stress on depression. To test specific hypotheses about the role of 5-HTTLPR variation on depression, we will perform coordinated meta-analyses of de novo results obtained from all available data, using variables and analyses determined a priori. Primary analyses, based on the original 2003 report by Caspi and colleagues of a GxE interaction will be supplemented by secondary analyses to help interpret and clarify issues ranging from the mechanism of effect to heterogeneity among the contributing studies. Publication of this protocol serves to protect this project from biased reporting and to improve the ability of readers to interpret the results of this specific meta-analysis upon its completion.
Language eng
DOI 10.1186/1471-244X-13-304
Field of Research 170102 Developmental Psychology and Ageing
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2013, BioMed Central Ltd
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30062560

Document type: Journal Article
Collections: School of Psychology
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Created: Fri, 25 Apr 2014, 19:46:59 EST by Craig Olsson

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.